| 肝硬化病人血清TNF-α.Ⅳ型胶原蛋白水平的研究 |
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| 引用本文： | 陆晓青,冉江华,郭群,张家华,孙辉. 肝硬化病人血清TNF-α.Ⅳ型胶原蛋白水平的研究[J]. 中国微创外科杂志, 1999, 0(2) |
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| 作者姓名： | 陆晓青 冉江华 郭群 张家华 孙辉 |
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| 作者单位： | 昆明医学院第二附属医院肝胆研究室 650101(陆晓青，冉江华，郭群，张家华)，昆明医学院第二附属医院肝胆研究室 650101(孙辉) |
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| 摘 要： | 目的:为探讨肝硬化病人Ⅳ型胶原(CⅣ)和肿瘤坏死因子(TNF-a)在肝硬化病中的临床意义。方法:对30例肝硬化病人应用双抗体夹心法检测血清CⅣ.TNF-a水平。结果:肝硬化病人血清CⅣ·TNF-a含量较对照组升高(P<0.05),血清CⅣ与TNF含量两者变化相一致。结论:血清CⅣ含量升高能反映肝纤维化的程度,TNF-a参与肝纤维化的形成。
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| 关 键 词： | 肝硬化 Ⅳ型胶原纤维(CⅣ) 肿瘤坏死因子(TNF-a) |
A study on serum levels of type IV collagen and TNF-a in patients with liver cirrhosis |
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| Lu Xiaoqin,Ran Jianhua,Guo Qun et al The second affiliated hospital of kunming medical college. A study on serum levels of type IV collagen and TNF-a in patients with liver cirrhosis[J]. Chinese Journal of Minimally Invasive Surgery, 1999, 0(2) |
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| Authors: | Lu Xiaoqin Ran Jianhua Guo Qun et al The second affiliated hospital of kunming medical college |
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| Affiliation: | kunmin city 650101 |
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| Abstract: | Objective: To study the clinical significance ot serum type IV collagen (C IV) and INF-a levels in patients with liver cirrhosis. Methods: Serum levds of CIV and TNF-a were measured by means of EILSA. Results:The serum levels of CW and TNF-a in patients with liver cirrhosis were higher than that in controls (P<0. 05). Conculusions: The increase of serum concentration of CIV may indicate early fibro-genic tendency in patients with liver cirrhosis. TNF-a was involved in the formation of hapatic fibrosis. |
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| Keywords: | Liver cirrhosis TNF-a collagen Type IV |
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