朝鲜族2型糖尿病与诸微效基因多态性的相关性及交互作用

目的]探讨朝鲜族SLC30A8,CDKN2A/B,HHEX和IRS-l等基因多态性与2型糖尿病(T2DM)的相关性及交互作用.方法]用多因子降维法(MDR)分析313例朝鲜族T2DM患者及178例健康对照者的SLC30A8(rs13266634),CDKN2A/B(rs10811661),HHEX(rs7923837)和IRS-l(rs1801278)等基因多态性的交互作用.结果]朝鲜族T2DM患者CDKN2A/B(rs10811661)基因的T等位基因频率与对照组比较差异有统计学意义(P<0.01).3位点rs13266634-rs10811661-rs7923837模型为最佳模型(P=0.000 3;Odd Ratio:2.063 2;95%CI:1.391 4³.059 4),且交叉验证一致性系数最大(10/10).结论]朝鲜族T2DM患者CDKN2A/B(rs10811661)基因的T等位基因可能与T2DM易感性相关.rs13266634,rs10811661,rs7923837基因位点之间可能存在基因-基因交互作用,rs13266634与rs7923837 2个SNP间的交互作用占主导地位.

Correlation and interaction between minor genes and type 2 diabetes mellitus in Korean-Chinese

OBJECTIVE To stdudy the correlation and interaction between Korean-Chinese SLC30A8,CDKN2A/B,HHEX and IRS-l gene polymorphism and type 2diabetes mellitus（T2DM）.METHODS Interaction of SLC30A8rs13266634,CDKN2A/B rs10811661,HHEX rs7923837 and IRS-l rs1801278 gene polymorphisms in 313 cases of Korean-Chinese T2 DM and 178 cases of healthy control were analyzed by MDR method.RESULTSThe CDKN2A/B（rs10811661）gene T allele frequency Korean-Chinese T2 DM patients had statistically significant differences as compared with control group（P〈0.01）,and The model of three loci of rs13266634,rs10811661 and rs7923837was the best model（P=0.000 3;Odd Ratio：2.0632;95%CI：1.391 4-3.059 4）,and the cross validation consistency coefficient was maximum（10/10）.CONCLUSIONThe CDKN2 A T/B（rs10811661）gene allele of Korean-Chinese T2 DM patients may be associated with T2 DM susceptibility,and The three loci of Rs13266634,rs10811661 and rs7923837has the gene-gene interaction between genetic loci,and the interaction between two SNP of rs13266634 and rs7923837is dominant.