CA125和HE4联合监测在子宫内膜癌诊断中的临床价值

目的：研究CA125争HE4联合监测在子宫内膜癌诊断中的临床价值。方法：应用酶联免疫吸附法和放射免疫法测定子宫内膜癌，功能障碍性子宫出血（功血）及子宫内膜癌妇女各30倒的HE4和CA125的表达水平，比较三组闻CA125和HE4的表达情况，CA125和HE4联合检洲用于子宫内膜癌诊断的特异性及敏感度。结果：①子宫内膜癌患者组的血清HE4水平显著高于功血组及健康对照组。对子宫内膜癌诊断的敏感度为36．67％，特异度96．67％。②CA125在子宫内膜癌中的表达水平显著高于其他两组，差异有显著意义，诊断子宫内膜癌的敏感度30％，特异度96．17％。⑧CA125和HE4联合检测诊断子宫内膜癌的敏感度63．33％，特异度93．33％。结论：CA125和HE4联合检测子宫内膜癌具有更好的诊断价值。

Clinical value of combined detection of CA125 and HE4 in diagnosis of endometrial carcinoma

Objective： To research clinical significance of combined detection of CA125 and HE4 in diagnosis of endometrial carcinoma. Methods： we detected the serum levels of HE4 and CA125 in 30 women with endometrial carcinoma, 30 women with dysfunctional uterine bleeding and 30 healthy women by ELISA and radioimmunoassay, and compared expressions of CA125 and HE4 among the three groups, together with sensitivities and specificities of HE4,CA125 and combined detection of HE4 and CA125 in the three groups. Results： The serum level of HE4 in endometrial carcinoma group was obviously higher than those in the other two groups. The sensitivity and specificity of HE4 detection in diagnosis of endometrial Carcinoma were 36. 67% and 96.67%. The sensitivity and specificity of CA125 detection in diagnosis of endometrial carcinoma were 30. 00% and 96. 17%. The sensitivity and specificity of combined detection of serum HE4 and CA125 was 63. 33% and 93.33%. Conclusion： Combined detection of serum HE4 and CA125 has a higher diagnostic value.