高血压性脑梗死患者血清超敏C反应蛋白及颈动脉粥样硬化关系的研究

目的探讨高血压性脑梗死患者血清超敏C反应蛋白与动脉粥样硬化之间的关系。方法选取58例高血压性脑梗死患者、46例原发性高血压患者及50例正常对照者，分别检测其血清超敏C反应蛋白及颈动脉粥样硬化指标，进行比较。结果高血压性脑梗死组血清超敏C反应蛋白水平高于原发性高血压组及正常对照组，颈动脉粥样硬化程度明显重于其他两组；高血压性脑梗死有斑块组血清超敏C反应蛋白水平高于原发性高血压有斑块组，差异有统计学意义（P〈0．05）。结论高血压患者存在明显的炎性反应，而这一反应在高血压性脑梗死患者中更明显。高血压性脑梗死患者血清超敏C反应蛋白与颈动脉粥样硬化存在明显的相关性。及早对高血压患者进行抗炎治疗或许会有助于脑梗死的预防。

Correlative study on high sensitivity C-reactive protein and carotid atherosclerosis in cerebral infarction patients withessential hypertension

Objective To deplore the relationship between serum high-sensitivity C-reactive protein（hs-CRP） and carotid atherosclerosis in cerebral infarction（CI）patients with essential hypertension.Methods 58 cases of CI with essential hypertension, 46 cases of essential hypertension and 50 healthy cases were enrolled. Serum hs-CRP levels and carotid atherosclerosis were detected and compared among them.Results Serum hs-CRP level in CI patients with essential hypertension was higher than that in the other two groups,so was the degree of carotid atherosclerosis.The level of serum hs-CRP with positive plaques in CI patients complicated with essential hypertension was higher than that in essential hypertension patients.The difference had statistically significance （P〈0.05）.Conclusion Inflammatory reaction exists in essential hypertension patients,and is more obvious in CI patients complicated with essential hypertension. Hs-CRP is closely correlated with carotid atherosclerosis plaques, and early anti-inflammation treatment may be useful in the prevention of CI in essential hypertension patients.