芬太尼透皮贴与吗啡治疗癌痛效果的Meta分析

目的：评价芬太尼透皮贴和吗啡缓释片在控制中重度癌痛的效果及不良反应的情况。方法以“芬太尼透皮贴∕多瑞吉∕吗啡∕美菲康∕癌症∕癌痛∕随机∕对照”为关键词，检索公开发表的相关随机对照试验。根据澳大利亚JBI循证卫生保健中心对RCT的评价原则进行文献评价，采用RevMan 5．0软件对本系统评价关注的结局指标进行M eta分析。结果共纳入10篇文献，疼痛缓解率差异无统计学意义，头晕嗜睡、恶心呕吐、便秘发生率差异有统计学意义。结论芬太尼透皮贴剂和口服吗啡控释片治疗中重度癌痛的效果相近，但芬太尼透皮贴剂头晕嗜睡、恶心呕吐、便秘等主要不良反应的发生率较低。

Meta-analysis for the treatment of cancer pain by Fentanyl transdermal patches and oral Morphine

Objective To evaluate the effect of fentanyl transdermal patches and release morphine tablets for the control of moderate to severe cancer pain and adverse reactions by meta-analysis .Method“Fentanyl transdermal patches /Durogesic /morphine /Meifeikang/cancer/cancer pain/random /control” was selected as key words ,the relevant published randomized controlled trials was retrieved based on databases .Literature was evaluated by RCT evaluation principles based on JBI evidence-based health care centers in Australia ,RevMan5 .0 software was used for meta-analysis to evaluate the system concern outcomes index .Result The meta-analysis included 10 trials .Remission rate of pain in both fentanyl transdermal patches and controlled-release oral morphine tablets was no significant difference .There were significant difference in incidence of dizziness ,drowsiness ,nausea ,vomiting and constipation .Conclusion Both fentanyl transdermal and controlled-release oral morphine tablets had the same effect in the treatment of patients with moderate to severe cancer pain ,but the former might have lower incidence of adverse reaction .