Thyroid dysfunction following mantle radiotherapy for Hodgkin's disease |
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| Authors: | N Nair S H Advani K A Dinshaw |
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| Affiliation: | 1. Aquatic Microbiology Laboratory, School of Fisheries, Aquaculture, and Aquatic Sciences, 203 Swingle Hall, Auburn University, Auburn, AL 36849, USA;2. Auburn University Shellfish Laboratory, 150 Agassiz Street, Dauphin Island, AL 36528, USA;1. Department of Earth and Planetary Sciences, Washington University, St. Louis, MO 63130, USA;2. Department of Geological Sciences, University of Missouri, Columbia, MO 65211, USA;3. OVSICORI-UNA, Heredia, Costa Rica;4. Department of Geology, Bates College, Lewiston, ME 04240, USA;5. Nasa Ames Research Center, Moffett Field, CA 94035, USA |
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| Abstract: | Thyroid function tests and scans were performed in 63 disease-free patients 6 months to 9 years following mantle radiotherapy for Hodgkin's disease. Evidence of abnormal thyroid function was seen in 27 patients (42.85%). Of these 27, 20 patients had TSH elevation as the only abnormality (31.7%). All but one were clinically euthyroid and none had any thyroid enlargement. Lipoidol lymphangiography was performed in 26 patients. Sixteen of these had abnormal function tests (61.5%) as against 11 from the 37 who had no lymphangiography done (29.7%).Twenty five patients returned for follow up studies between 1 and 2 years after the first visit: 7 of these patients who had elevated TSH values initially, returned to normal at this time. It was found from this study that abnormalities of thyroid function following external radiation to the neck are more biochemical than clinical. |
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