| 甲氨蝶呤吸干乳剂的抗肿瘤作用 |
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| 引用本文： | 晏四平,曾红,苏德森. 甲氨蝶呤吸干乳剂的抗肿瘤作用[J]. 沈阳药科大学学报, 2000, 17(3): 160-163 |
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| 作者姓名： | 晏四平 曾红 苏德森 |
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| 作者单位： | 1. 北京生物制品研究所
2. 沈阳药科大学药学系,沈阳,110015 |
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| 摘 要： | 用吸干乳剂作为抗癌药物甲氨蝶呤 (MTX)的载体 ,考察MTX对S1 80 、H2 2 、ESC 3种实体瘤和EAC腹水瘤的抑制作用 ,并初步考察了MTX制成吸干乳剂后对小鼠的毒性 .结果表明 :与MTX片剂相比 ,吸干乳剂能提高MTX对 3种实体瘤和EAC的抑制作用
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| 关 键 词： | 吸干乳剂 甲氨蝶呤 抗肿瘤 |
| 修稿时间： | :1999-10-1 |
A Study on the Antitumor Effects of the Methotrexate Dry Adsorbed Emulsion |
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| Yan Siping,Zeng Hong,Su Desen. A Study on the Antitumor Effects of the Methotrexate Dry Adsorbed Emulsion[J]. Journal of Shenyang Pharmaceutical University, 2000, 17(3): 160-163 |
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| Authors: | Yan Siping Zeng Hong Su Desen |
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| Abstract: | Dry adsorded emulsion,as a new antitumor drug delivery system,was used to entrap the methotrexate(MTX).The antitumor effects of methotrexate dry adsorbed emulsion(MTXDAE)were studied on three solid tumors(Sarcosma180,Hepatoma22 and Ehrlich Solid carcinoma) and Ehrlich ascites carcinoma,and the preliminary toxicity test of the MTXDAE was also studied in this paper.The results showed that the dry adsorbed emulsion could increase the antitumor effects of the MTX on three solid tumors and EAC in mice,especially in higher doses. |
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| Keywords: | dry adsorbed emulsion methotrexate antitumor effects |
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