布地奈德吸入治疗小儿急性感染性喉炎疗效观察

目的 探讨布地奈德吸入治疗小儿急性感染性喉炎疗效.方法 选取2010年1月至2012年1月收治的急性感染性喉炎168例,分为常规治疗组80例,布地奈德组88例观察两组临床疗效.结果 布地奈德组总有效率97.72 %,常规治疗组总有效率80.00 %,两组总有效率比较,有显著差异性(P<0.05).结论 布地奈德混悬液是临床上应用吸入糖皮质激素唯一品种,具有高度亲脂性,直接作用于气道,抑制变态反应、抗炎作用是氢化可的松的600倍,地塞米松的20～30倍,丙酸倍氯米松的2倍;可使微小血管收缩,炎症渗出减少,减轻水肿,清除呼吸道炎症;常规治疗剂量中不会产生全身不良反应,不会出现皮质醇增多症.总之,布地奈德吸入治疗小儿急性感染性喉炎疗效确切,应用方便,是治疗急性喉炎首选方法.

The curative effect observation of budesonide inhalation in treatment of acute infectious laryngitis

Objective To investigate the treatment with inhaled budesonide in children with acute infectious laryngitis effect.Methods From 2010 January to 2012 year in January from acute infectious laryngitis in 168 cases,divided into the routine treatment group 80 cases,88 cases of budesonide group observes two groups of clinical curative effect.Results The budesonide group total effective rate 97.72%,the conventional treatment group total effective rate was 80%,total effective rate between the two groups have significant difference at(P<0.05).Conclusion Budesonide suspension is on the clinical application of inhaled corticosteroids only breed,is highly lipophilic,a direct role in the airway,inhibiting allergic reaction,anti-inflammatory effect is 600 times of hydrocortisone,dexamethasone 20～30 times,beclomethasone dipropionate 2 times.The tiny vasoconstriction,reduced inflammatory exudate,relieve edema,clearance of airway inflammation.Conventional treatment dose does not produce systemic adverse reactions,does not appear in hypercortisolism.In conclusion,budesonide inhalation in treatment of acute infectious laryngitis curative effect,convenient application,is the preferred method of treatment of acute laryngitis.