磷酸西格列汀联合胰岛素治疗2型糖尿病疗效观察

目的 观察磷酸西格列汀联合胰岛素治疗2型糖尿病的临床疗效.方法 选取在我院接受胰岛素治疗至少8周的2型糖尿病患者20例,入选后测定身高、体重、空腹及餐后血糖、糖化血红蛋白值,记录胰岛素用量.给予磷酸西格列汀100mg/d口服,并根据定期血糖监测情况适时调整胰岛素用量,经过4周联合治疗后,观察患者BMI、空腹及餐后血糖、糖化血红蛋白值的变化.结果 联合磷酸西格列汀治疗4周后,患者HbA1c、FBG显著降低(P＜0.01)；2hBG明显降低(P＜0.05)；胰岛素用量较前明显减少(P＜0.01)；BMI较前无明显改变(P＞0.05).结论 磷酸西格列汀联合胰岛素治疗2型糖尿病有明显疗效,且可以减少患者胰岛素用量,降低低血糖风险,降低体重,无明显胃肠道不良反应.

Effect observation on treatment of type 2 diabetes with sitagliptin phosphate tablets and insulin

Objective To observe the effect of combination of sitagliptin phosphate tablets and insulin on type 2 diabetes.Methods 20 patients with T2DM were selected,all patients had insulin treatment at least 8 weeks.The patients took sitagliptin 100mg/d and insulin,and adjusted insulin timely.4 weeks later the FBG,2hBG,HbA1c,BMI and the dosage of insulin per day were tested.Results After 4 weeks combination therapy of sitagliptin and insulin,HbA1c,FBG and the insulin they needed were reduced significantly(P<0.01),2hBG was also reduced(P<0.05);However,BMI was not changed obviously(P>0.05).Conclusion Combination of sitagliptin and insulin can significantly decrease blood glucose of type 2 diabetes patients,reduce insulin and control body weight.