| 薏苡仁酯对人鼻咽癌细胞周期的影响 |
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| 引用本文： | 李毓,胡祖光,胡笑克. 薏苡仁酯对人鼻咽癌细胞周期的影响[J]. 华夏医学, 2004, 17(2): 131-132 |
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| 作者姓名： | 李毓 胡祖光 胡笑克 |
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| 作者单位： | 广东省中医研究所,广东,广州,,510095;中山医科大学核医学教研室,广东,广州,,510089 |
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| 基金项目： | 广东省自然科学基金资助课题 (970839) |
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| 摘 要： | 目的：探讨薏苡仁酯(coixenolide，CXL)对人鼻咽癌CNE-2Z细胞周期的作用。方法：采用微量细胞克隆形成法检测CNE-2Z细胞的增殖能力和对药物的敏感性，用流式细胞仪分析细胞周期时相。结果：CXL以量效方式抑制CNE-2Z细胞的克隆形式，ID50-10^-5.003mol／L。小剂量、短时问使细胞阻滞于S期，大剂量、长时间则停留在G2／M期。结论：CXL通过作用于S期或G2／M期而抑制CNE-2Z细胞生长。
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| 关 键 词： | 鼻咽肿瘤 细胞周期 慧苡仁酯 药物作用 |
| 文章编号： | 1008-2409(2004)02-0131-02 |
| 修稿时间： | 2003-11-10 |
Effect of Coixenolide on Cell Cycle in Human Nasopharyngeal Carcinoma Cells |
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| LI Y u,HU Zu guang,HU Xiao keGuangdong Provincial Institute of Traditional Chinese Medicine,Guangzhou ,China. Effect of Coixenolide on Cell Cycle in Human Nasopharyngeal Carcinoma Cells[J]. Acta Medicinae Sinica, 2004, 17(2): 131-132 |
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| Authors: | LI Y u HU Zu guang HU Xiao keGuangdong Provincial Institute of Traditional Chinese Medicine Guangzhou China |
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| Affiliation: | LI Y u,HU Zu guang,HU Xiao keGuangdong Provincial Institute of Traditional Chinese Medicine,Guangzhou 510095,China |
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| Abstract: | Objective: To study the effect of coixenolide (CXL) on c ell cycle in human nasopharyngeal carcinoma (NPC) cell line CNE 2Z. Methods: Mi crocolony form ation assay was used in determining the sensitivity of CNE 2Z to CXL.Cell cycle phases were analyzed with flow cyto metry. Results: CXL dose dependently inhibited the CNE 2Z colony f ormation, with ID 50 =10 -5.003 mol/L.The treated cells were blocked in S phase in l ow dose or short time exposure, G 2/M phase in high dosage or long time. Concl usio n: CXL can suppress the generation of CZE 2Z cells by its interference with DNA synthesis and mitosis. |
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| Keywords: | nasopharyngeal carcinoma cell cycle coixenolide drug action |
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