Stage-dependent secretion of ABP by rat seminiferous tubules |
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Authors: | E M Ritzen C Boitani M Parvinen F C French M Feldman |
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Affiliation: | 1. Pediatric Endocrinology Unit, Karolinska Hospital, S-104 01 StockholmSweden;2. Institute of Biomedicine, Department of Anatomy, University of Turku, SF-20520 Turku 52 Finland;3. Department of Pediatrics, University of North Carolina, School of Medicine, Chapel Hill, NC 27514 U.S.A. |
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Abstract: | The secretion rate of the Sertoli-cell-specific androgen-binding protein (ABP), has been studied in isolated rate seminiferous tubules, where the stages of the spermatogenic cycle have been identified by a transillumination method. The secretion of ABP was highest in stages VII-XII, as determined by steady-state polyacrylamide-gel electrophoresis as well as by radioimmunoassay. More specifically, when the sensitive RIA technique permitted the assay of ABP secretion from a total amount of 10-30 mm of isolated tubules, it was found that maximal ABP secretion occurred at stages VIII-XI and minimal at stages IV-V. The present results show that the secretory activity of the Sertoli cells (ABP) is influenced by the type of germ cell at each cell association. It is postulated that the variation is Sertoli-cell secretory activity is of importance for the normal maintenance of spermatogenesis. |
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Keywords: | androgen-binding protein Sertoli cell FSH testosterone protein synthesis |
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