盐酸丙帕他莫在腔镜肺大疱切除术后镇痛中的应用

目的:研究盐酸丙帕他莫对胸腔镜下肺大疱切除术患者术后镇痛效果的影响.方法:60例行胸腔镜下肺大疱切除手术患者随机分为2组.盐酸丙帕他莫组手术结束前给予盐酸丙帕他莫2 g,ivd;芬太尼组手术结束前给予芬太尼2μg·kg-1,iv.观察记录2组苏醒时平均动脉压(MAP)、心率(HR)及拔管时间,对2组患者苏醒后10 min(T1),术后1 h(T2)、2h(T3)、3 h(T4)及4 h(T5)的疼痛程度进行视觉模拟(VAS)评分.结果:2组患者苏醒时的MAP及HR差异无统计学意义(P>0.05),盐酸丙帕他莫组拔管时间比芬太尼组明显缩短,术后T3、T4、T5时点VAS评分明显低于芬太尼组(P<0.05).结论:盐酸丙帕他莫对胸腔镜下肺大疱切除术后患者镇痛效果确切.

Applications of Propacetamol in the Postoperative Pain Treatment after Video assisted Pulmonary Bulla Resection

Objective:To study the efficacy of propacetamol in the postoperative pain treatment after video-assisted pulmonary bulla resection.Method:Sixty patients undergoing video-assisted pulmonary bulla resection were randomly divided into 2 groups.In the propacetamol group,the patients were injected 2 g propacetamol intravenously at the end of the surgery.In the fentanyl group,the patients were injected 2μg ·kg^-1fentanyl intravenously at the end of the surgery.The mean arterial pressure（MAP）,heart rate（HR） and the extubation time were recorded.Pain visual analogue scale（VAS）at 10 min（T₁）,.1 h（T₂）,2 h（T₃）,3 h（T₄）and 4 h（T₅） after the extubation was evaluated.Result:No significant difference in MAP and HR between the two groups was shown when the patients recovered from the anesthesia（P>0.05）.In the propacetamol group,the extubation time was much shorter than that in the fentanyl group（P < 0.05）.Postoperative VAS score of the propacetamol group was lower than that of the fentanyl group at T₁ and T₂, however,with no significant difference（P>0.05）.But the scores of the propacetamol group were obviously lower than those of the fentanyl group at T₃,T₄ and T₅（P <0.05）.Conclusion:Propacetamol exhibits excellent postoperative analgesic effect in the postoperative pain treatment after video-assisted pulmonary bulla resection.