| 正交试验结合 CCD 响应面法优化绿丝郁金酒炙工艺研究 |
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| 引用本文： | 权亮,赵永峰,陈志敏,周海婷,李文兵,胡昌江. 正交试验结合 CCD 响应面法优化绿丝郁金酒炙工艺研究[J]. 时珍国医国药, 2019, 0(4): 855-858 |
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| 作者姓名： | 权亮 赵永峰 陈志敏 周海婷 李文兵 胡昌江 |
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| 作者单位： | 成都中医药大学;成都市中草药研究所;国家中医药管理局"中药配方颗粒质量与疗效评价"重点研究室;四川新绿色药业科技发展有限公司 |
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| 基金项目： | 国家中药标准化项目(ZYBZH-Y-SC-42;ZYY-2017-151) |
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| 摘 要： | 目的优化绿丝郁金酒炙工艺。方法以HPLC法测定酒郁金中吉马酮和莪术呋喃二烯酮的含量作为评价指标,采用正交试验结合CCD响应面法,对影响绿丝郁金酒炙工艺的3个因素进行筛选和优化。结果绿丝郁金最佳酒炙工艺为:每100 g绿丝郁金饮片,加入10 mL黄酒与6.5 mL水的混合液,拌匀闷润,118℃炒制5 min即得。验证实验结果表明该工艺条件重复性良好,具有合理性和可行性。结论采用正交实验和CCD响应面法优选的绿丝郁金酒炙工艺稳定可行,可用于其炮制工艺的优化。
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| 关 键 词： | 绿丝郁金 酒炙工艺 正交实验 CCD响应面法 莪术呋喃二烯酮 吉马酮 |
Optimization of processing technology of Curcuma. Phaeocaulis Val. by orthogonal design and central composite design response surface methodology |
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| QUAN Liang,ZHAO Yong-feng,CHEN Zhi-min,ZHOU Hai-ting,LI Wen-bing,HU Chang-jiang. Optimization of processing technology of Curcuma. Phaeocaulis Val. by orthogonal design and central composite design response surface methodology[J]. Lishizhen Medicine and Materia Medica Research, 2019, 0(4): 855-858 |
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| Authors: | QUAN Liang ZHAO Yong-feng CHEN Zhi-min ZHOU Hai-ting LI Wen-bing HU Chang-jiang |
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| Affiliation: | (Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Key Laboratory of Chinese Medicine Formulations particle Mass and Clinical Evaluation,Chengdu 611900,China;Neo-Green Pharmaceutical Co,Ltd,Chengdu 611900,China;Chengdu Institute of Chinese Herbal Medicine,Chengdu 610016,China) |
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| Abstract: | QUAN Liang;ZHAO Yong-feng;CHEN Zhi-min;ZHOU Hai-ting;LI Wen-bing;HU Chang-jiang(Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Key Laboratory of Chinese Medicine Formulations particle Mass and Clinical Evaluation,Chengdu 611900,China;Neo-Green Pharmaceutical Co,Ltd,Chengdu 611900,China;Chengdu Institute of Chinese Herbal Medicine,Chengdu 610016,China) |
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| Keywords: | C. Phaeocaulis Val. Processing technology The Plackett-Burman design Central composite design response surface method Curcuma furano gestodene Entropy method Germacrone |
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