Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. paul@tropmedres.ac
Abstract:
A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria.