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Early treatment failure in severe malaria resulting from abnormally low plasma quinine concentrations |
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| Authors: | Newton Paul N Ward Steven Angus Brian J Chierakul Wirongrong Dondorp Arjen Ruangveerayuth Ronnatrai Silamut Kamolrat Teerapong Pramote Suputtamongkol Yupin Looareesuwan Sornchai White Nicholas J |
| Institution: | Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand. paul@tropmedres.ac |
| Abstract: | A patient admitted with severe Plasmodium falciparum malaria in western Thailand had an early treatment failure with quinine, despite full dosing. Plasma quinine concentrations were subtherapeutic. Abnormal quinine pharmacokinetics may explain sporadic reports of quinine treatment failures in severe malaria. |
| Keywords: | Malaria Plasmodium falciparum Quinine Pharmacokinetics Treatment failure Thailand |
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