| 3％高渗盐水不同给药方式治疗重型颅脑损伤的临床研究 |
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| 引用本文： | 陈涛,全凯,蔡菁.3％高渗盐水不同给药方式治疗重型颅脑损伤的临床研究[J].浙江创伤外科,2011,16(4):433-436. |
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| 作者姓名： | 陈涛 全凯 蔡菁 |
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| 作者单位： | 浙江大学医学院附属第二医院,杭州,310009 |
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| 基金项目： | 浙江省医药卫生科学研究基金 |
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| 摘 要： | 目的探讨3％高渗盐水（HS）不同给药方式治疗重型颅脑损伤的效果及副作用。方法将53例颅脑损伤患者随机分为高渗盐水治疗组（A、B组）和甘露醇治疗组（C组），A组采用静脉单次熏复给药，输注剂量为4ml／kgq6h徊组采用静脉持续滴注，维持速度为lml／kg／h；C组为20％甘露醇125ml静脉快速滴注q6h。监测患者ICP、CVP及第三天电解质和肾功能情况。结果与用药前相比，用药后12小时3组患者的ICP均无统计学差异（P〉0．05），而HS组患者中心静脉压在用药后明显升高（P〈0．05）。用药后3天A、B组患者血钠、尿素氮、肌酐均无显著改变（P〉0．05）；C组血尿素氮、肌酐值较同期HS组明显升高（P〈0．05）。结论3％高渗盐水降低颅脑外伤后颅内压效果显著，副作用小，建议使用快速滴注的给药方式。
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| 关 键 词： | 高渗盐水 甘露醇 颅脑损伤 给药方式 |
Clinical study on application of 3% hypertonic saline in treatment of sever traumatic brain injury with different administration methods |
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| CHEN Tao,QUAN Kai,CAI Jing.Clinical study on application of 3% hypertonic saline in treatment of sever traumatic brain injury with different administration methods[J].Zhejiang Journal of Traumatic Surgery,2011,16(4):433-436. |
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| Authors: | CHEN Tao QUAN Kai CAI Jing |
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| Institution: | CHEN Tao,QUAN Kai,CAI Jing. The Second Affiliated Hospital of Zhejiang University School of Medicine,Zhejiang 310009,China |
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| Abstract: | Objective To evaluate the curative and side effects of 3% hypertonic saline (HS) with different inJection ways in treatment of sever traumatic brain injury (TBI). Methods 53 patients with severe TBI were randomly divided into three groups. Group A (16 patients) were treated with venous infusion of 3% HS repeatly (4ml/kg, q6h). Group B (17 patients) were treated with venous infusion of 3% HS continuously (1ml/kg/h). Group C (20 patients) were treated with venous infusion of 20% mannitol (125ml). Intracranial... |
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| Keywords: | Hypertonic saline Mannitol Severe traumatic brain inJury Administration methods |
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