| Anti-inflammatory and ulcerogenic effects of 3-(N,N-diethylamino)propylindometacin HCl |
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| 引用本文： | 黄志力,鹿儿岛正丰,香川荣一郎,王尉青,岛田英世. Anti-inflammatory and ulcerogenic effects of 3-(N,N-diethylamino)propylindometacin HCl[J]. Acta pharmacologica Sinica, 1997, 0(4) |
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| 作者姓名： | 黄志力 鹿儿岛正丰 香川荣一郎 王尉青 岛田英世 |
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| 作者单位： | 北里大学药学部临床药理学教室 |
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| 摘 要： | 目的：考察盐酸３（Ｎ，Ｎ二乙胺）丙基吲哚美辛（ｐｒｏｄｒｕｇ）抗炎及致溃疡作用．方法：观察大鼠角叉菜胶（Ｃａｒ）性炎症反应及口服给药胃溃疡指数的变化．结果：腹腔给药显著抑制Ｃａｒ性趾水肿，３ｈ及５ｈ的抑制率分别为３６５７％和３４５６％，与等摩尔浓度的吲哚美辛（Ｉｎｄ）差异无显著性；足趾１０μｇ／ｐａｗ给药达到６４％的抑制率，再增加剂量不能增加效果；１４１８ｍｇ·ｋｇ－１的ｐｒｏｄｒｕｇ灌胃６小时后溃疡指数显著低于同摩尔数Ｉｎｄ．结论：该药为一抗炎作用强，致溃疡性低的药物．
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| 关 键 词： | 3-（N，N-二乙胺）丙基吲哚美辛；吲哚美辛；角叉菜胶；水肿；胃溃疡 |
Anti-inflammatory and ulcerogenic effects of 3-( N,N-diethylamino)-propylindometacin HCl |
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| HUANG Zhi Li ,KAGOSHIMA Masatoyo,KAGAWA Eiichiro,WANG Wei Qing,SHIMADA Hideyo. Anti-inflammatory and ulcerogenic effects of 3-( N,N-diethylamino)-propylindometacin HCl[J]. Acta pharmacologica Sinica, 1997, 0(4) |
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| Authors: | HUANG Zhi Li KAGOSHIMA Masatoyo KAGAWA Eiichiro WANG Wei Qing SHIMADA Hideyo |
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| Affiliation: | HUANG Zhi Li 1,KAGOSHIMA Masatoyo,KAGAWA Eiichiro,WANG Wei Qing,SHIMADA Hideyo |
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| Abstract: | |
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| Keywords: | 3 ( N N diethylamino) propyl-indo-methacin indomethacin carrageenan edema stomach ulcer |
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