| Study on Lymphocyte Activation and Proliferation Induced by Anti-CD3 McAb |
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| 作者姓名： | 李鸣 杨敬 沈关心 张茜 刘慎沛 刘忠北 叶维新 |
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| 作者单位： | LI Ming;YANG Jing;SHEN Guan-xin(Department of Immunology，Reseach Center of Experimental Medicine，Tongji Medical University，Wuhan |
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| 摘 要： | ＳｔｕｄｙｏｎＬｙｍｐｈｏｃｙｔｅＡｃｔｉｖａｔｉｏｎａｎｄＰｒｏｌｉｆｅｒａｔｉｏｎＩｎｄｕｃｅｄｂｙＡｎｔｉ－ＣＤ３ＭｃＡｂＬＩＭｉｎｇ（李鸣）；ＹＡＮＧＪｉｎｇ（杨敬）；ＳＨＥＮＧｕａｎ－ｘｉｎ（沈关心）（ＤｅｐａｒｔｍｅｎｔｏｆＩｍｍｕｎｏｌ...
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Study on Lymphocyte Activation and Proliferation Induced by Anti-CD3 McAb |
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| LI Ming,YANG Jing,SHEN Guan-xin.Study on Lymphocyte Activation and Proliferation Induced by Anti-CD3 McAb[J].Journal of Zuazhong University of Science and Technology: Medical Edition,1994(4). |
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| Authors: | LI Ming YANG Jing SHEN Guan-xin |
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| Abstract: | T cell activation and proliferation via CD3-TCR complex were investigated by lymphocyte DNA synthesis in vitro.Several interfering factors were also discussed.The result indicated that lymphocyte activation and proliferation are calciumdependent.A rise of cytoplasmic free Ca2+ quickly following activation with CD3 McAb is mainly due to intracellular mobilization of Ca2+,while lymphocyte proliferation needs both intracellular mobilization of Ca2+ as well as influx of extracellular Ca2+, It was confirmed that CTX sensitive G protein plays a role in regulating T cell proliferation by pretreatment with CTX suppressing lymphocyte H-TdR incorporation obviously.PLC and PKC inhibitor neomycin and P.S.S could also decrease T cell proliferation. |
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| Keywords: | CD_3 McAb lymphocyte activation and proliferation GTP-binding protein cytoplasmic free calcium |
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