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| 五味子多糖抗变态反应活性新发现 | |
| 引用本文： | 刘淼,张朝晖,潘俊芳,王顺春,施松善.五味子多糖抗变态反应活性新发现[J].中成药,2012,34(4):629-632. |
| 作者姓名： | 刘淼 张朝晖 潘俊芳 王顺春 施松善 |
| 作者单位： | 1. 江苏大学药学院,江苏镇江,212013 2. 上海华拓医药科技发展股份有限公司,上海,201203 3. 上海中医药大学中药研究所中药标准化教育部重点实验室,上海,201210 |
| 摘 要： | 目的 比较未脱蛋白和脱蛋白五味子多糖组的药理活性的抗变态反应活性和多糖组成,并探讨其作用机制.方法 利用Finigen Trace DSQ GC-MS(TR-5MS柱)对五味子粗多糖进行单糖组成测定,通过小鼠耳异种被动皮肤过敏试验(小鼠PCA实验)和腹腔肥大细胞脱颗粒实验观察五味子多糖的抗变态反应药理作用.结果 五味子粗多糖主要是由D-葡萄糖、D-半乳糖及D-半乳糖醛酸组成,其具有稳定肥大细胞、抑制肥大细胞脱颗粒的作用,其中未脱蛋白部位较脱蛋白部位活性更强.结论 五味子多糖提取物具有抗Ⅰ型变态反应的功效,并且未脱蛋白部位较脱蛋白部位抗变态反应活性更强. |
| 关 键 词： | 五味子多糖 未脱蛋白多糖组 脱蛋白多糖组 抗变态反应 被动皮肤过敏实验 肥大细胞脱颗粒 |
Anti-type-I hypersensitivity of Schisandra chinensis polysaccharide |
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| LIU Miao , ZHANG Zhao-hui , PAN Jun-fang , WANG Shun-chun , SHI Song-shan.Anti-type-I hypersensitivity of Schisandra chinensis polysaccharide[J].Chinese Traditional Patent Medicine,2012,34(4):629-632. | |
| Authors: | LIU Miao ZHANG Zhao-hui PAN Jun-fang WANG Shun-chun SHI Song-shan |
| Institution: | 1.Pharmaceutical College,Jiangsu University,Zhenjiang 212013,China;2.Shanghai Hotmed Sciences Co.,Ltd.Shanghai 201203,China;3.Key Laboratory of Standardization of Chinese Medicines,Ministry of Education,Institute of Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201210,China) |
| Abstract: | AIM To study the effect of deproteinization of Schisandra chinensis polysaccharide on hypersensitivity.METHODS Finigen Trace DSQ GC-MS was used to assay the composition of Schisandra chinensis polysaccharide.The experiment of passive cutaneous anaphylaxis(PCA) and degranulation in peritoneal mast cells were applied to the observation on the mice’s hypersensitivity.RESULTS Schisandra chinensis polysaccharide consisted of D-glucose,D-galactose and D-galacturonic acid.Polysaccharide without deproteinization and polysaccharide with deproteinization inhibited the degranulation of mast cells,but the latter had the greater activity.CONCLUSION Schisandra chinensis polysaccharide has an antagonistic effect on type-I-hypersensitivity,and polysaccharide without deproteinization has greater activity than polysaccharide with deproteinization. |
| Keywords: | Schisandra chinensis polysaccharide polysaccharide without deproteinization polysaccharide with deproteinization anti-hypersensitivity passive cutaneous anaphylaxis mast cell degranulation |
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