芪参益气滴丸治疗女性冠心病稳定性心绞痛的临床研究

目的观察芪参益气滴丸治疗女性冠心病稳定性心绞痛气虚血瘀证的临床疗效及安全性。方法将80例女性冠心病稳定性心绞痛气虚血瘀证患者随机分为治疗组(45例)和对照组(35例),对照组给予硝酸甘油治疗,治疗组在对照组基础上加用芪参益气滴丸,疗程均为6周。观察治疗后心绞痛疗效、硝酸甘油服停减率,比较治疗前后心电图、超敏C-反应蛋白(hs-CRP)、内皮素(ET)、一氧化氮(NO)的变化。结果治疗后治疗组在心绞痛疗效,心电图,硝酸甘油停减率改善方面优于对照组,差异均有统计学意义(P<0.01或P<0.05);两组治疗前后hs-CRP、ET、NO各项指标以及治疗后两组间比较差异均有统计学意义(P<0.01或P<0.05)。结论芪参益气滴丸治疗女性气虚血瘀型冠心病稳定性心绞痛安全有效。

Clinical study of Qishen Yiqi Dropping Pills on female patients with stable angina pectoris

AIM To observe the clinical effects and safety of Qishen Yiqi Dropping Pills on female patients with stable angina pectoris(syndrome of Qi deficiency and blood stasis).METHODS Eighty patients were randomly divided into two groups,treatment group(n=45) and control group(n=35).The control group was treated with nitroglycerin.The treatment group was treated with Qishen Yiqi Dropping Pills and nitroglycerin.All courses of treatment were 6 weeks.The therapeutic effects on angina pectoris,nitroglycerin withdrawal rate and changes in electrocardiogram(ECG),high-sensitivity C-reactive protein(hs-CRP),endothelial(ET) and nitric oxide(NO) were observed before and after the treatment.RESULTS The total efficiency on angina pectoris,ECG and nitroglycerin withdrawal rate in the treatment group showed significant difference in improving angina pectoris and ECG compared with the control group(P<0.01 or P<0.05).There were significant differences in the indexes of hs-CRP,ET,NO before and after the treatment in both groups themselves and between the two groups after the treatment(P<0.01 or P<0.05).CONCLUSION Qishen Yiqi Dropping Pills are effective and safe on female patients with stable angina pectoris.