甘桔冰梅片联合质子泵抑制剂治疗胃食管反流病致慢性咽炎的疗效观察

目的 探讨甘桔冰梅片(桔梗、薄荷、乌梅、甘草、冰片、射干、蝉蜕、青果)联合质子泵抑制剂( PPI)治疗胃食管反流病致慢性咽炎的疗效.方法 选取具有慢性咽炎表现的胃食管反流病患者114例,随机分成3组:单纯PPI组35例,PPI联合健民咽喉片组31例,PPI联合甘桔冰梅片组48例.评估治疗后患者症状改善、咽部局部体征及药物不良反应的情况.结果 114例患者有112例完成实验,经治疗4周后,3组患者症状评分均明显低于治疗前,PPI联合甘桔冰梅片组治疗后症状评分又明显低于PPI组和PPI联合健民咽喉片组,PPI联合甘枯冰梅片组治疗后有效率明显高于PPI组和PPI联合健民咽喉片组;在局部体征改善情况,联合甘桔冰梅片组治疗后明显高于PPI组和PPI联合健民咽喉片组;3组病人经治疗4周后,均未出现严重不良反应.结论 甘桔冰梅片联合质子泵抑制剂能安全、有效地改善胃食管反流病致慢性咽炎的症状.

Clinical effect of Ganjie Bingmei Tablet combined with proton pump inhibitors on chronic pharyngitis complicated by gastroesophageal reflux disease

AIM To observe clinical effect of Ganjie Bingmei Tablet(Platycodi Radix,Methae Herba,Mume Fructus,Glycyrrhizae Radix et Rhizoma,Borneolum syntheticum,Belamcandae Rhizoma,Cicadae periostracum,Canarii Fructus) with proton pump inhibitors(PPIs) on chronic pharyngitis complicated by gastroesophageal reflux disease(GERD).METHODS One hundred and fourteen patients with chronic pharyngitis complicated by GERD were randomly divided into three groups: the PPI group,the PPI and Jianmin Yanhou Tablet group,the PPI and Ganjie Bingmei Tablet group.The symptom improvement localized signs of the throat and adverse drug reactions were observed before and after treatment in three groups.RESULTS There were 112 patients completed the experiment in 114 patients.After four weeks treatment,the symptom scores in three groups were significantly lower than the scores before treatment.The symptom scores of PPI and Ganjie Bingmei Tablet group after treatment were also significantly lower than those of the PPI group and the PPI and Jianmin Yanhou Tablet group.The effective rate of the PPI and Ganjie Bingmei Tablet group after treatment was significantly higher than that of the PPI group and the PPI and Jianmin Yanhou Tablet group.Improvement of the local signs in the PPI and Ganjie Bingmei Tablet group after treatment was significantly higher than that of the PPI group and the PPI and Jianmin Yanhou Tablet group.There were no serious adverse reactions in three groups after four weeks treatment.CONCLUSION Ganjie Bingmei Tablet combined with proton pump inhibitors can safely and effectively improve symptoms of chronic pharyngitis caused by gastroesophageal reflux disease.