Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat |
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Authors: | G Karadeniz Cakmak O Irkorucu B H Ucan A U Emre B Bahadir C Demirtas O Tascilar K Karakaya S Acikgoz G Kertis H Ankarali H Pasaoglu M Comert |
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Institution: | 1. Department of Surgery, The School of Medicine, Zonguldak Karaelmas University, Kozlu-Zonguldak, Turkey 6. Arastirma ve Uygulama Hastanesi Bashekimligi, Zonguldak Karaelmas Universitesi, 67600, Kozlu-Zonguldak, Turkey 2. Department of Pathology, The School of Medicine, Zonguldak Karaelmas University, Kozlu-Zonguldak, Turkey 4. Department of Biochemistry, The School of Medicine, Gazi University, Besevler-Ankara, Turkey 3. Department of Biochemistry, The School of Medicine, Zonguldak Karaelmas University, Kozlu-Zonguldak, Turkey 5. Department of Biostatistics, The School of Medicine, Zonguldak Karaelmas University, Kozlu-Zonguldak, Turkey
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Abstract: | Background Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with
additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This
study was designed to assess its effects on the healing process of colonic anastomosis.
Methods Thirty-two male Wistar albino rats were randomized into two groups and subjected to colonic anastomosis. The study group was
treated with simvastatin and the control group received only tap water instead. The rats were killed 3 and 7 days postoperatively.
Wound complications, intra-abdominal abscesses, and anastomotic leaks and stenosis were recorded. Four types of assessment
were performed: bursting pressure, hydroxyproline content, histopathology, and biochemical analysis.
Results Compared to the control group, simvastatin-treated rats displayed a higher bursting pressure (p < 0.001) and anastomotic hydroxyproline content (p < 0.05). Simvastatin treatment leads to a significant decrease in malondealdehyde levels (p < 0.05) and increase in paraoxonase activity (p < 0.001) at both time points. Histopathological analysis revealed that simvastatin administration leads to a better anastomotic
healing in terms of reepithelialization, decreased granuloma formation, reduced ischemic necrosis, and inflammatory infiltration
to muscle layer.
Conclusion Clinically relevant doses of simvastatin do not have a negative impact on colonic anastomosis but improve intestinal wound
healing in rats.
Oral presentation at the “Turkish National Surgery Congress”, Antalya, Turkey, May 2008. |
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Keywords: | Simvastatin Wound healing Anatomosis Dehiscence Bursting pressure Hydroxyproline |
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