老年人血脂与颈动脉斑块形成的临床相关性研究

目的研究老年人颈动脉粥样硬化斑块形成的多种危险因素,同时探讨血脂与颈动脉斑块形成之间的相关性。方法收集2009年5月成都地区60岁以上干部人群139例体检资料,根据颈动脉彩超结果分为无斑块组（59例）与有斑块组（80例）,将两组的多种危险因素（如年龄、血脂、血压）进行统计学和二项分类Logistic回归分析,并对血脂四项指标绘制ROC曲线评价其对颈动脉斑块的预测价值。结果老年人颈动脉有斑块组与无斑块组年龄、收缩压比较差异有统计学意义（P〈0.05）,而两组血脂四项、血糖、血肌肝、血尿酸、BMI、吸烟比较差异无统计学意义（P〉0.05）。两组资料中年龄、血脂、血压之间的二项分类Logistic回归筛选影响颈动脉斑块的因素,结果年龄及SBP进入回归方程,血脂四项均被排除。血脂四项指标的ROC曲线下面积小于0.6（P〉0.05）,对有无斑块形成没有预测价值。结论老年人颈动脉粥样硬化及斑块形成主要受年龄及收缩压影响,而血脂四项指标对颈动脉斑块形成的影响不确切,血脂对颈动脉有无斑块形成没有预测价值。

Relation between Blood-lipid and Carotid Plaques Formation in Senile

Objective To evaluate the influence of risk factors on arteriosclerotic plaques formation in the senile with carotid arteriosclerosis and to evaluate relation between blood-lipid and carotid arteriosclerotic plaques.Methods One hundred and thirty-nine cases（≥60 years old） were collected and divided into 2 groups according to signs of color Doppler ultrasonoscope of carotid： No plaque group（n=59） and plaque plaque（n=80）.Age,blood-lipid,and BP were evaluated by statistics and binomial distribution Logistic regression analysis.Four indexes of blood-lipid were drawn a ROC curve in order to assess predictive value of carotid arteriosclerotic plaques.Results There were significantly differences in age and SBP in 2 groups（plaque group and no plaque group）（P〈0.05）.There were no differences of blood-lipid,blood glucose,blood creatinine,blood uric acid,BMI and smoking（P〉0.05）.Age,blood-lipid and BP were analyzed by binomial distribution logistic regression analysis.Influencing factor of carotid atheromatous plaque formation was screened.Age and SBP were related with carotid plaque formation.Blood-lipid was not related with carotid plaque formation.Conclusion Senile carotid arteriosclerosis and plaques formation are influenced by age and SBP.Blood-lipid（including LDL） could not predict carotid atheromatous plaque formation.