养血清脑颗粒治疗缺血性脑血管病后焦虑抑郁的临床观察

目的观察养血清脑颗粒对缺血性脑血管病后焦虑抑郁的治疗作用及药物的安全性。方法根据入选条件选取缺血性脑血管病后焦虑抑郁的患者83例,其中急性缺血性脑卒中患者41例,慢性脑供血不足患者42例,随机分为对照组、实验1组、实验2组,实验1组给予帕罗西汀片和养血清脑颗粒,实验2组给予养血清脑颗粒,对照组给予帕罗西汀片,共口服药物8周。分别于治疗前后进行汉密尔顿抑郁量表（HAMD）评分、汉密尔顿焦虑量表（HAMA）评分。结果缺血性脑血管病后焦虑抑郁以头痛头晕、情绪低落、睡眠障碍为主。治疗后实验1组较对照组HAMD评分下降明显（P〈0.05）,对照组及实验1组HAMD、HAMA评分均较实验2组降低明显（P〈0.05）。实验1组的总有效率为96.4%,实验2组的总有效率为81.5%,对照组的总有效率为92.5%,3组总有效率差异无统计学意义（P〉0.05）,但3组减分率构成比差异有统计学意义（P〈0.05）。结论养血清脑颗粒对于缺血性脑血管病后焦虑抑郁有治疗作用,药物安全可靠,副反应少。

Clinical Observation on Yangxue Qingnao Granules for Treatment of Ischemic Cerebrovascular Disease Comorbid Depression and Anxiety Disorders

Objective To explore the effect of Yangxue Qingnao granules（YQG）for treatment of ischemic cerebrovascular disease comorbid depression and anxiety disorders after ischemic cerebrovascular disease.Methods Eighty-three patients（pts） with ischemic cerebrovascular disease comorbid depression and anxiety disorders were randomly divided into the control group treated with paroxetine,the experimental group 1 given paroxetine and Yangxueqingnao granules,and experimental group 2 given YQG for eighe weeks.The Hamilton Depression（HAMD） and Hamilton Anxiety（HAMA） scores were collected before and after treatment.Results Headache dizziness,depressed mood,sleep disturbances were the primarily symptoms of ischemic cerebrovascular disease comorbid depression anxiety.After treatment,the HAMD score in control group was more obviously reduced than that in experimental group 1（P〈0.05）.The HAMD and HAMA scores in control group and experimental group 1 were more obviously reduced than that in experimental group 2（P〈0.05）.The total effective rate was 81.5% in experimental group 2,96.4% in experimental 1 groups,and 92.8% in control group（P〉0.05）.There were no obvious adverse reactions during treatment.Conclusion YQG was effective and safety for ischemic cerebrovascular disease comorbid depression symptoms.