| 早期瑞舒伐他汀干预对不稳定型心绞痛支架术后血清妊娠相关蛋白A和高敏C反应蛋白的影响 |
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| 引用本文： | 翁建新,刘强,左辉华,王丽丽,张敏州,魏熠,陈绮映.早期瑞舒伐他汀干预对不稳定型心绞痛支架术后血清妊娠相关蛋白A和高敏C反应蛋白的影响[J].中医药研究,2011(7):781-783. |
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| 作者姓名： | 翁建新 刘强 左辉华 王丽丽 张敏州 魏熠 陈绮映 |
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| 作者单位： | [1]广东省深圳市孙逸仙心血管医院、深圳市心血管病研究所,518102 [2]广东省中医院,518102 |
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| 摘 要： | 目的探讨瑞舒伐他汀对血脂水平正常的不稳定型心绞痛患者行PCI术后妊娠相关蛋白A（PAPP-A）及高敏C反应蛋白（hs-CRP）的影响。方法 56例血脂水平正常的不稳定型心绞痛患者,随机分为瑞舒伐他汀组和常规治疗组,两组患者分别于PCI术前、术后24 h、术后1个月检测血清PAPP-A和hs-CRP水平。结果两组患者术后24 h与术前比较,血清PAPP-A和hs-CRP浓度均有明显升高,但两组间比较,无明显差异;术后1个月,两组血清PAPP-A和hs-CRP水平与术后24 h比较,均有回降,但瑞舒伐他汀组较常规治疗组回降更为明显,两者存在统计学意义（P〈0.05）。结论早期使用瑞舒伐他汀能更有效降低不稳定型心绞痛患者PCI术后PAPP-A和hs-CRP水平。
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| 关 键 词： | 瑞舒伐他汀 不稳定型心绞痛 妊娠相关蛋白A 高敏C反应蛋白 经皮冠脉介入治疗 |
Influence of Rosuvastatain on Plasma PAPP-A and hs-CRP after PCI in Unstable Angina Pectoris |
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| Institution: | Weng Jianxin,Liu Qiang,Zou Huihua,et al Sun Yatsen Cardiovascular Hospital,Shenzhen(Shenzhen 518102) |
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| Abstract: | Objective To investigate the effects of rosuvastatain on the pregnancy-associated plasma protein-A（PAPP-A） and high sensitivity C-reactive protein（hs-CRP） after percutaneous coronary intervention（PCI） in patients（pts） with unstable angina pectoris（UAP）.Methods Fifty-six pts with UAP were randomly divided into two groups：Rosuvastatain group（n=30） treated with rosuvastatain and control group（n=26） treated with routine treatment.The levels of PAPP-A and hs-CRP were detected before PCI and at 24 hours,1 month after PCI.Results The levels of PAPP-A and hs-CRP were increased at the 24 hours after PCI in two groups（P0.05）.The levels of PAPP-A and hs-CRP were decreased at 1 month after PCI in two groups（P0.05）.The levels of PAPP-A and hs-CRP were obviously lower than that in control group（P0.05）.Conclusion Rosuvastatain could decrease the level of PAPP-A and hs-CRP significantly in pts with UAP after PCI. |
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| Keywords: | Rosuvastatain unstable angina pectoris pregnancy-associated plasma protein-A high sensitivity C-reactive protein percutaneous coronary intervention |
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