| 冠心病稳定型心绞痛患者MPO及MMP-9表达变化 |
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| 引用本文： | 宋庆桥,李宜,胡元会,冯玲,石洁,吴华芹,曹雪滨,李俊峡. 冠心病稳定型心绞痛患者MPO及MMP-9表达变化[J]. 中医药研究, 2011, 0(6): 653-656 |
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| 作者姓名： | 宋庆桥 李宜 胡元会 冯玲 石洁 吴华芹 曹雪滨 李俊峡 |
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| 作者单位： | [1]于中国中医科学院广安门医院,100053 [2]中国中医科学院研究生院 ,100053 [3]中国人民解放军第二五二医院 ,100053 [4]白求恩国际和平医院,100053 |
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| 基金项目： | 为国家十一五科技支撑项目（No.2006BAI21B04） |
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| 摘 要： | 目的 探讨冠心病稳定型心绞痛患者血清髓过氧化物酶（MPO）和基质金属蛋白酶-9（MMP-9）表达变化.方法 采用液相芯片分析系统同步检测206例经冠状动脉造影证实的稳定型心绞痛患者及28名健康对照者血清MPO和MMP-9表达程度,并分析其与冠脉病变程度的相关性.结果 稳定型心绞痛患者血清MPO、MMP-9表达程度较健康对照者升高（P〈0.01）;二者变化具有显著正相关（P〈0.01）,且与冠脉病变程度Gensini积分无明显相关.结论 稳定型心绞痛患者冠脉斑块具有一定程度炎性反应和不稳定性,其中表达程度升高者可能处于向不稳定型心绞痛过度的阶段.MPO和MMP-9可能成为判定稳定型心绞痛患者危险分层的依据.
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| 关 键 词： | 稳定型心绞痛 髓过氧化物酶 基质金属蛋白酶-9 |
Expression of Myeloperoxidase and Matrix Metalloproteinase-9 in Stable Angina Pectoris |
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| Affiliation: | Song Qingqiao,Li Yi,Hu Yuanhui,et al Guang＇anmen Hospital,China Academy of Chinese Medical Sciences(Beijing 100053) |
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| Abstract: | Objective To explore the expression of myeloperoxidase（MPO） and matrix metalloproteinase-9（MMP-9） in patients（pts） with stable angina pectoris（SAP）.Methods By liquid-chip analysis system,the expression of MPO and MMP-9 in 206 pts with SAP and 28 subjects were detected and compared.Results The expression of MPO and MMP-9 in pts with SAP was obviously higher than that in health subjects（P0.01）.There was significant positive relation between MPO and MMP-9（P0.01）.Conclusion There were some degree inflammatory reactions in coronary plaques in pts with SAP.The pts with high level of MPO and MMP-9 might trend to develop unstable angina pectoris.MPO and MMP-9 could provide a basis for risk stratification of SAP. |
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| Keywords: | stable angina pectoris myeloperoxidase matrix metalloproteinase-9 |
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