| 丙型肝炎病毒感染与原发性肝癌的关系——不同人群血清HCV RNA的调查 |
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| 引用本文： | 杨建民,刘为纹,晋华源. 丙型肝炎病毒感染与原发性肝癌的关系——不同人群血清HCV RNA的调查[J]. 第三军医大学学报, 1993, 0(2) |
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| 作者姓名： | 杨建民 刘为纹 晋华源 |
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| 作者单位： | 第三军医大学西南医院消化内科 630038(杨建民,刘为纹),第三军医大学西南医院消化内科 630038(晋华源) |
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| 摘 要： | 本文以聚合酶链反应(PCR)对重庆地区各种慢性肝病(CLD,n=182)和献血员(n=35)血清HCV RNA的存在状况进行了初步调查。结果发现:①HCV RNA在原发性肝癌(PHC)、肝硬化(LC)、慢性肝炎(CH)及献血员中的检出率分别为36.6％(34/93)、31.7％(20/63)、15.4％(4/26)和2.9％(1/35);②多数HCV RNA阳性CLD(41/58)与HBsAg或HBV DNA双阳性,单纯HCV RNA阳性见于15.1％(14/93)PHC、3.2％(2/63)LC和3.8％(1/26)CH。此资料提示约20％PHC可能与HCV-HBV双重感染有关,约15％PHC可能与单独HCV感染有关。
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| 关 键 词： | 丙型肝炎病毒 乙型肝炎病毒 聚合酶链反应 肝肿瘤 |
The relationship between hepatitis C virus infection and primary hepatic carcinoma: An investigation on serum HCV RNA in different populations |
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| Yang Jianmin,Liu Weiwen,Jin Huayuan. The relationship between hepatitis C virus infection and primary hepatic carcinoma: An investigation on serum HCV RNA in different populations[J]. Acta Academiae Medicinae Militaris Tertiae, 1993, 0(2) |
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| Authors: | Yang Jianmin Liu Weiwen Jin Huayuan |
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| Abstract: | A preliminary investigation on the serum HCV RNA in 182 patients with different chronic liver diseases and 35 blood donors was performed with "nested" polymerase chair reaction.The findings were as follows;(1)Serum HCV RNA was detected in 36.6%(34/93)cases of primary hepatic carcinoma(PHC),31.7%(20/63)cases of liver cirrhosis(LC),15.4%(4/ 26)cases of chronic hepatitis(CH)and 2.9%(1/35)blood donors.(2)Most of the HCV RNA positive cases were accompanied with positive serum HBsAg/HBV DNA.15.1%(14/93)of PHC,3.2%(2/63)of LC and 3.8%(1/26)of CH was positive only for HCV RNA.The findings suggest that about 20% of PHC are related to the coinfection of HCV and HBV,while 15% of PHC are related to HCV infection only. |
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| Keywords: | hepatitis viral human hepatitis B virus hepatoma polymerase chain reaction |
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