Application of dermal microdialysis for the determination of bioavailability of clobetasol propionate applied to the skin of human subjects |
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Authors: | Au W L Skinner M F Benfeldt E Verbeeck R K Kanfer I |
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Affiliation: | Rhodes University, Grahamstown, South Africa. |
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Abstract: | Dermal microdialysis was used to assess the bioavailability of a topical corticosteroid, clobetasol propionate, following application onto the skin of human subjects. The penetration of clobetasol propionate from a 4% m/v ethanolic solution applied onto 4 sites on one forearm of healthy human volunteers was studied. A lipid emulsion, Intralipid?, was used as the perfusate and linear microdialysis probes with a 2-kDa cutoff were inserted intradermally at the designated sites. The results indicated that Intralipid could be used as a suitable perfusate for in vivo microdialysis of this lipophilic drug of interest. Furthermore, the study clearly demonstrated the application of dermal microdialysis as a valuable tool to assess the bioavailability/bioequivalence of clobetasol propionate penetration into the skin following topical application. |
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