镁锌合金与大鼠肠道的生物相容性

背景:镁合金在骨科已进行一些初步研究,有较好的生物相容性,目前尚未在肠道进行相关基础研究.目的:镁锌合金植入大鼠盲肠,观察其与大鼠的生物相容性.方法:取SD大鼠随机区组法分为镁合金组、纯钛组和假手术组,镁合金组在盲肠切口周围包埋长约5 mm×1 mm×1 mm镁锌合金条,纯钛组植入相同尺寸的医用纯钛条,假手术组仅做缝合.于术前、术后第7,14,21,28天,观察血清谷草转氨酶、肌酐、镁离子浓度;植入材料区X射线片;肝、肾和材料植入区盲肠病理学变化.结果与结论:各组同一时间节点血清谷草转氨酶、肌酐、镁离子浓度的差异无显著性意义(P>0.05);镁锌合金逐步降解,28 d时部分降解;肝肾盲肠病理无明显异常.结果提示,镁锌合金对肠道无明显影响,其降解时间发挥固定功能时间长于肠道愈合时间,且有较好的生物相容性,可用作胃肠吻合器所用到的吻合钉.

Biocompatibility of a magnesium-zinc alloy implanted in rat cecum

BACKGROUND: Magnesium alloy studies in orthopedic field have been carried out,and good biocompatibility has been reported.However magnesium alloys have not yet been researched in the intestine.OBJECTIVE: The biodegradable magnesium-zinc alloy samples are implanted around the rat cecum to investigate the biocompatibility in rat.METHODS: Sprague Dawley rats were randomly divided into magnesium alloy group,medical titanium group and the sham-operated group.Then magnesium-zinc alloy samples with the dimension of 5 mm × 1 mm× 1 mm were embedded in the cecum incision in the magnesium alloy group.The medical titanium was embedded in the medical titanium group,and just suture in the sham-operated group.Prior to surgery and at 7,14,21 and 28 days after operation,the serum glutamic-oxaloacetic transaminase,creatinine and magnesium ion concentration were examined in each group.X-ray film on implanted region.The pathological changes in liver,kidney and cecum were examined.RESULTS AND CONCLUSION: There were no significant differences in serum glutamic-oxaloacetic transaminase,creatinine and magnesium ion concentrations among each group(P > 0.05).Magnesium-zinc alloy degraded gradually during 28 days.The pathology of liver,kidney and cecum was normal.Results suggested that magnesium-zinc alloy had no obvious effect on the cecum.The degradation time to play a fixed function of time was longer than the intestinal healing time,with good biocompatibility.Magnesium-zinc alloy can be used as anastomotic nail for stomach intestine anastomat.