| 远志属植物的皂苷类成分及其药理作用研究进展 |
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| 引用本文： | 傅晶,张东明,陈若芸.远志属植物的皂苷类成分及其药理作用研究进展[J].中草药,2006,37(1):144-146. |
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| 作者姓名： | 傅晶 张东明 陈若芸 |
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| 作者单位： | 中国医学科学院,中国协和医科大学药物研究所,北京,100050 |
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| 基金项目： | 国家自然科学基金资助项目(20372087,20432030)，回国人员科研启动项目 |
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| 摘 要： | 远志属植物在我国多数被药用,具有益智安神、镇咳祛痰之功效,现代药理研究还发现其具有降糖和免疫增强等活性。该属植物主要含有皂苷、酮及寡糖多酯等成分,其中皂苷是该属植物的主要活性成分之一,苷元均为齐墩果烷型三萜,糖的种类有葡萄糖、鼠李糖、木糖、芹糖、半乳糖等。现对该类成分的化学结构、波谱学特征及现代药理研究进行总结,以利于这类植物的进一步研究、开发与利用。
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| 关 键 词： | 远志属 皂苷 谱学特征 生物活性 |
| 文章编号： | 0253-2670（2006）01-0144-03 |
| 收稿时间： | 2005-01-20 |
| 修稿时间： | 2005-01-20 |
Advances in studies on saponins and the irpharmacological activities in plants of Polygala L. |
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| FU Jing,ZHANG Dong-ming and CHEN Ruo-yun.Advances in studies on saponins and the irpharmacological activities in plants of Polygala L.[J].Chinese Traditional and Herbal Drugs,2006,37(1):144-146. |
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| Authors: | FU Jing ZHANG Dong-ming and CHEN Ruo-yun |
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| Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Objective To elucidate the ESI-MS performance of lipophilic tanshinones and to establish a fingerprint of lipophilic tanshinones of Radix Salviae Miltiorrhiza.Methods The lipophilic tanshinones were extracted by ultrasonic wave with 95% ethanol from Radix Salviae Miltiorrhiza and the extracts were analyzed directly in positive ion mode by electrospray ion trap mass spectrometry(ESI-MS).Results The lipophilic tanshinones were easily to form molecular ions ~ and dimeric sodium adduct ions ~ in positive ion mode,molecular ions of lipophilic tanshinones were fragmentated through lossing H_2O,CO and A-ring cleavages in ESI-MS~2.The ESI-MS fingerprints of lipophilic tanshinone extracts with 14 selected characteristic peaks analyzed with SPSS software were characteristic and stable.Conclusion Lipophilic tanshinones have similar ESI-MS performance;the ESI-MS fingerprint is a useful tool for a rapid and special identification of lipophilic tanshinones in selected traditional Chinese medicine. |
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| Keywords: | Polygala L saponin spectral characteristic biological activity |
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