维生素E等药物抗动脉粥样硬化的作用

目的　探寻维生素E、氨氯地平、辛伐他汀抗动脉粥样硬化 (AS)的共同机制。方法　在高胆固醇饮食基础上建立兔AS模型 ,随机分组 ,检测各组兔主动脉AS面积、全血超氧化物歧化酶 (SOD)活力、血清丙二醛 (MDA)含量及血清脂质浓度。结果　与模型组相比 ,3组用药组主动脉AS面积均显著减少 (P <0 0 1) ,SOD活力明显升高 (P<0 0 1) ,MDA含量下降 (P <0 0 1) ,且以辛伐他汀组变化最显著。辛伐他汀组血清总胆固醇 (TC)、低密度脂蛋白胆固醇 (LDL -C)、甘油三脂 (TG)较模型组显著降低 (P <0 0 1)。结论　脂质过氧化物减少和SOD活力增加可能是维生素E、氨氯地平、辛伐他汀抗AS作用的共同机制。

Study of common mechanisms of antiatherosclerotic effects of Vitamin E, amlodipine and simvastatin

Objective To seek the common mechanisms of antiatherosclerotic effects of vitamin E,amlodipine and simvastatin.Methods New Zealand White rabbits were fed regular chow,c how with 1% cholesterol and 2% pigoil,1% cholesterol and 2% pig oil diet plused lo vastatin,1% cholesterol and 2% pig oildiet plused vitamin E or 1% cholesterol an d 2% pig oil diet plused amlodipine for 24 weeks.The extent of aortic atherosclero sis ,serum malondlialdehyde(MDA) and superoxide dismutase(SOD) in blood was measu red respectively.Results Compared with modelgroup,the groups given vitamin E,amlodipine or simvastatin with a high cholesterol diet had significantly less atherosclerosis(P<0.01).The serum MDA levels were lower in the groups given vitanlin E,amlodipine or simvastatin dlan model group(P<0.01).Blood SOD act ivity was higher in the groups given vitamin E,amlodipine or simvastatin than th at of mo del group(P<0.01).Compared with model group,the levels of TC,LDL-C,TG in sim vastatin group decreased markedly(P<0.01). Conclusion A reduction in lipid peroxidation and preserva tion of SOD may be common mechanisms of antiatherosclerotic effects of vitamin E ,amlodipine and simvastatin.