心肌肌钙蛋白Ⅰ在急性心肌梗死中的应用价值

目的探讨心肌肌钙蛋白Ⅰ(cTnI)、心肌酶谱测定在急性心肌梗死中诊疗监测的敏感性和可靠性.方法使用美国康仁ACS180,采用化学发光法进行定量测定cTnI,以＞0.2ng/ml为阳性;采用日立7600全自动生化分析仪检测心肌酶谱,以CK＞184.0 u/L,CK-MB＞24.0 u/L,AST＞38.0 u/L,LDH＞250.0 u/L为阳性.结果 AMI胸痛发生后弘18h,血清cTnI敏感性最高,持续时间最长,最长达13～15 d,其诊断AMI的敏感性及有效性明显高于CK,CK-MB,AST和LDH.结论心肌肌钙蛋白Ⅰ是一种心肌损伤的特异性标志物,对诊断AMI有重大的临床意义.

Value of cTnI in acute myocardial infarction

Objective: To assess the sensibility and reliability of myocardial troponin (cTnI) and myocardial enzyme spectrum on the patients with acute myocardial infarction(AMI). Method: The level of cTnI was measured by chemical fluorescent analysis method of Amrican CHIRON ACS180, and the result was positive when the level of cTnI was greater than or equal to 0.2 ng/ml. The alteration of myocardial enzyme spectrum was measured by HITACHI76000 Automobile Biochemical Appliance, and the positive result was CK>18.0 u/L, CK-MB>24.0 u/L, AST>38.0 u/L, LDH>50.0 u/L. Result: The serum level of cTnI kept high sensibility from 3 to 18 hours after AMI happened, and the serum level of cTnI could be tested until 15 days after AMI happened. The serum cTnI was more sensitive than CK, CK-MB, AST, LDH in diagnosing of AMI. Conclusion: cTnI serve as a specific marker for AMI, which may be useful in diagonosing AMI.