Effect of NO-synthase inhibitor L-NAME on occlusion and reperfusion arrhythmias in cats |
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| Authors: | O I Kukushkina L K Fedotkina V P Balashov L A Balykova A A Sosunov |
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| Institution: | (1) Department of Faculty Therapy, Department of Cytology, Histology, and Embryology, N. P. Ogarev Mordovian State University, Saransk |
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| Abstract: | On the model of occlusion/reperfusion arrhythmia in cats it was shown that repeated injections of the NO-synthase inhibitor
L-NAME decreased the incidence of occlusion arrhythmias (to 40%), eliminated reperfusion-induced ventricular fibrillation,
and drastically reduced the latency of occlusion arrhythmias. A single injection of L-NAME (20 mg/kg) immediately before ligation
of the coronary artery did not decrease the incidence of occlusion and reperfusion arrhythmias.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 509–511, May, 1999 |
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| Keywords: | ventricular arrhythmias nitric oxide NO-synthase inhibitor |
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