男性甲亢患者治疗前后血清性激素水平观察

目的:探讨男性甲亢患者治疗前后血清性激素水平的变化及其临床意义。方法:采用化学发光免疫法测定68例男性甲亢患者治疗前后血清卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)和雌二醇(E2)的水平,并与对照组比较,进行统计学分析。结果:男性甲亢患者治疗前血清T和E2的水平明显高于对照组,差异有显著性(P<0.05);FSH、LH的水平与对照组相比差异无显著性(P>0.05)。男性甲亢患者治疗后血清FSH、LH、T和E2的水平与对照组相比差异无显著性(P>0.05)。结论:男性甲亢患者存在性激素代谢紊乱;患者血清T和E2水平的增高是机体为了适应高代谢环境,下丘脑-垂体-性腺轴所产生的适应性变化;随着甲亢得到控制,其水平恢复正常。

The Observation of Serum Sexual Hormone Levels Before and After Treatment in Male Hyperthyroidisms

Objective: To explore the changes of serum sexual hormone levels in male hyperthyroidisms before and after treatment. Methods: Compared with the control group,the serum folliclestimulating hormone(FSH),leuteinizing hormone(LH),testosterone(T) and estradiol(E_(2)) of 68 cases of male hyperthyroidisms before and after treatment were detected by chemiluminescence immunoassay technique,and then statistical analysis was performed.Results: The serum T and E_(2) levels of male hyperthyroidisms were significantly higher than those of the control group before treatment(P<(0.05));while no significant difference in FSH and LH levels existed between the patients and the control group(P>(0.05)).There was no difference in FSH,LH,T and E_(2) levels between patients and the control group after treatment(P>(0.05)).Conclusion: There are sexual hormone metabolism disorder in hyperthyroidism men,and the increasing serum T and E_(2) levels are only to adapt the high metabolism environment,and the changes of hypothalamus-pituitary-gonadal axes.Along with the control of hyperthyroidism,the sexual hormone levels return to normal.