| 丝裂原激活蛋白激酶相关疾病及其药物的研究进展 |
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| 引用本文： | 张美荣,刘举,王洋. 丝裂原激活蛋白激酶相关疾病及其药物的研究进展[J]. 中国药物化学杂志, 2014, 0(3): 231-240 |
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| 作者姓名： | 张美荣 刘举 王洋 |
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| 作者单位： | 辽宁大学药学院,辽宁沈阳110036 |
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| 摘 要： | 丝裂原激活蛋白激酶(MAPK)是保证人体功能正常运行的重要物质,它在细胞增殖、分化、凋亡、应激反应、炎症反应、免疫防御等过程中发挥着重要作用,MAPK异常可导致多种疾病(癌症、炎症、神经性疾病、糖尿病和高血压等)的发生。本文对丝裂原激活蛋白激酶异常导致的相关疾病、治疗药物以及作用机制方面的研究进展进行综述。
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| 关 键 词： | 丝裂原激活蛋白激酶 抗肿瘤 心血管疾病 炎症 糖尿病 |
Research progress of mitogen-activated protein kinase and related drugs |
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| ZHANG Mei-rong,LIU Ju,WANG Yang. Research progress of mitogen-activated protein kinase and related drugs[J]. Chinese Journal of Medicinal Chemistry, 2014, 0(3): 231-240 |
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| Authors: | ZHANG Mei-rong LIU Ju WANG Yang |
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| Affiliation: | ( College of Pharmacy, Liaoning University, Shenyang 110036, China) |
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| Abstract: | Recent literature about the role of mitogen-activated protein kinase （MAPK）to human body and its related drugs was reviewed. When some lesions occurs in the body, MAPK is abnormal accordingly. Mitogen-activated protease is an important material of the human body for the function to run properly, the excep- tion can lead to a variety of diseases. This review is about the progress of the role of MAPK in a variety of diseases, a novel target,including the basic introduction of mitogen-activated protease and the type of corresponding disease and new drugs. |
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| Keywords: | mitogen-activated protein kinase antitumor cardiovascular disease inflammation diabetes |
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