滋阴补肾对绝经后膝骨关节炎雌激素和C-反应蛋白表达的影响 |
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引用本文: | 俞益火,田治标,谢嫚花. 滋阴补肾对绝经后膝骨关节炎雌激素和C-反应蛋白表达的影响[J]. 中国中医骨伤科杂志, 2014, 0(3): 34-35 |
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作者姓名: | 俞益火 田治标 谢嫚花 |
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作者单位: | 重庆市梁平县人民医院骨科一病区,重庆梁平405200 |
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摘 要: | 目的:探讨滋阴补肾法对绝经后膝骨关节炎雌二醇(E2)和c-反应蛋白(CRP)表达的影响。方法:2012年2月-2013年3月在我院门诊就诊的86例绝经后膝骨关节炎患者随机分为滋阴补肾组(A组)、盐酸氨基葡萄糖组(B组)各43例。检测两组治疗前后雌二醇(E2)和c-反应蛋白(CRP)水平。结果:A组治疗后2、6周雌二醇(E2)和C-反应蛋白(CRP)表达改善明显优于B组(P〈0.05);A组在治疗后2、6周其膝关节评分和视觉模拟评分明显优于B组(P〈0.05)。结论:滋阴补肾法能有效改善绝经后膝骨关节的症状,可能通过调节雌二醇(E2)和C-反应蛋白(CRP)水平,实现改善关节软骨功能和减轻滑膜炎症的目的。
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关 键 词: | 滋阴补肾法 膝骨关节炎 绝经后 雌二醇(E2) C-反应蛋白(CRP) |
Effect of Ziyin Bushen Formula on Estradiol and C-reactive Protein in Patients with Postmenopausal Knee Osteoarthritis |
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Affiliation: | YU Yihuo,Tian Zhibiao, Xie Manhua No. 1 Division, Department of Orthopaedics, the People's Hospital of Liangping, Chongqing 405200, China |
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Abstract: | Objective.. To explore the effect of Ziyin Bushen Formula on estradiol and C-reactive protein in patients with post- menopausal knee osteoarthritis. Methods.. Eighty-six patients with postmenopausal knee osteoarthritis who were collected from clinic from February 2012 to March 2013 were randomly divided into group A (43 cases) and group B (43 cases) who respectively took Ziyin Bushen Formula and glucosamine hydrochloride capsules. The levels of estradiol and C-reactive protein before and after treatment were recorded. Results:Group A had more significant improvements than Group B on the levels of estradiol, C-reactive protein and score of JOA and VAS (P〈0.05) at the 2nd and the 6th week. Conclusion:Ziyin Bushen Formula could improve symptom and function of knee osteoarthritis via regulating the expression of estradiol and C- reactive protein. |
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Keywords: | Ziyin Bushen Formula Knee osteoarthritis Postmenopausal Estradiol C-reactive protein |
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