Calcification tendency of various biological aortic valves in an experimental animal model |
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| Authors: | Mirzaie M Meyer T Schorn B Schwartz P Baryalei M Rastan A Lotfi S Dalichau H |
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| Affiliation: | 1. CVPath institute, Gaithersburg, MD, United States;2. Office of the Chief Medical Examiner, Baltimore, MD, United States;3. University of Maryland, School of Medicine, Baltimore, MD, United States;1. School of Medicine, Oregon Health & Science University, Portland, Oregon;2. Knight Cardiovascular Institute, Oregon Health & Science University, Portland, Oregon;3. School of Public Health, Portland State University-Oregon Health & Science University, Portland, Oregon;4. Division of Cardiothoracic Surgery, Oregon Health & Science University, Portland, Oregon |
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| Abstract: | The present study aimed at investigating the influence of fixation methods on the ultrastructure and calcium content of five different aortic biovalves. Biovalves subcutaneously implanted in Wistar rats for 12 weeks demonstrated significant differences in their calcium contents. Using Scheffe tests, two different groups of biovalves could be distinguished: (i) valves with high calcium content, such as Toronto-SPV (165 +/- 42 mg/g dry tissue) and Intact (193 +/- 36 mg/g dry tissue), and (ii) valves with low calcium content, such as Mosaic (2.7 +/- 1.8 mg/g dry tissue), Freestyle (2.3 +/- 1.1 mg/g dry tissue) and Hancock-II (3.6 +/- 1.2 mg/g dry tissue) (P < 0.05). All biovalves with an ultrastructurally preserved endothelium exhibited a low calcification tendency. The data suggest that if the endothelium is lost as a result of the fixation procedure, then calcification can only be prevented by appropriate anticalcification methods. |
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