脑缺血危险因素与Alzheimer病

Alzheimer病(AD)是老年人最常见的痴呆类型,为一种神经变性疾病。传统观点认为,AD和血管性痴呆不论在发病机制和还是治疗上都是两种完全不同的痴呆类型,但是近年来越来越多的证据显示血管因素在AD的发生、发展中起着重要作用。文章对脑缺血及其危险因素,包括高血压、糖尿病、胆固醇等在AD的发生和发展中的作用做了综述,以期为预防和延迟AD的发生和进展提供新的策略。

Risk Factors of Cerebral Ischemia and Alzheimer's Disease

Alzheimer's disease (AD) is the most frequent type of dementia in elderly,which has been regarded as a neurodegenerative disease.The traditional point of view considers that AD and vascular dementia are two different types of dementias both from their pathogenesis and treatment;however,in recent years,a growing body of evidence indicates that the vascular factors are playing an important role in the development and occurrence of AD.This article reviews cerebral ischemia and its risk factors including the effects of hypertension,diabetes,and cholesterol in the development and occurrence of AD,so as to provide new strategies in preventing,and delaying the occurrence and progression of AD.