乳腺癌P53蛋白表达与淋巴结转移的相关性及预后意义

目的:探讨乳腺癌P53蛋白的表达临床意义。方法:应用免疫组织化学方法检测79例乳腺癌中P53蛋白的表达,分析P53蛋白表达与乳腺癌临床病理因素及淋巴结转移的相关性。结果:乳腺癌P53阳性率为46.84%,其表达与组织学分级、ER表达有相关性(P<0.01),而与患者年龄、肿瘤长径、TNM分期、病理学类型无关(P>0.05)。P53蛋白在乳腺癌中表达与淋巴结转移呈正相关(P<0.01)。单因素生存分析乳腺癌P53蛋白表达是影响其预后的因素(P<0.05)。多因素生存分析乳腺癌P53蛋白表达独立的预后因素(P<0.05)。结论:乳腺癌P53蛋白表达与淋巴结转移单、多因素生存分析是影响预后的重要因素。

The study of expression and prognostic significance of P53 and the relation to the nodal involvement in breast carcinoma

Objective: To investigate the clinicopathologic significance of P53 protein in breast carcinoma and the association of the expression of P53 protein with nodal involvement,and to evaluate their prognostic values.Methods:The expression of P53 protein in 79 breast carcinomas was measured by immunohistochemical method.The relation to the clinicopathologic features was analyzed.Results: The positive rate of P53 protein expression in breast carcinoma was 46.84%,and was only associated with differentiated Grade and ER status(P<0.01) among the clinicopathologic features.There was positive correlation between expression of P53 protein and nodal involvement(P<0.01).The Univariate analysis showed that P53 was a significant individual prognostic variable.Multivariate analysis showed that P53 also was an independent prognostic factor statistically.Conclusions: The positive rate of P53 protein expression in breast carcinoma was associated with nodal involvement.The Univariate and Multivariate analysis showed that P53 was an important independent prognostic factor statistically.