| 血管壁面剪切应力对动脉粥样硬化和动脉瘤的影响 |
| |
| 引用本文： | 李淑妍,陶新宇,曲晨. 血管壁面剪切应力对动脉粥样硬化和动脉瘤的影响[J]. 中国动脉硬化杂志, 2024, 32(5): 451-455 |
| |
| 作者姓名： | 李淑妍 陶新宇 曲晨 |
| |
| 作者单位： | 南京医科大学第二附属医院老年医学科,江苏省南京市 210011 |
| |
| 基金项目： | 国家自然科学基金面上项目(81971317) |
| |
| 摘 要： | 血管壁面剪切应力是血流动力学的重要参数,正常的壁面剪切应力维持了血管的生理状态,而异常的壁面剪切应力与动脉粥样硬化和动脉瘤的病理进展关系密切,是发生恶性心脑血管事件的危险因素之一。异常的壁面剪切应力通过不同发病机制破坏了内皮细胞的正常功能,介导这两种疾病的起始、演变。文章结合近几年来的文献研究,综述了壁面剪切应力对动脉粥样硬化和动脉瘤的影响。
|
| 关 键 词： | 壁面剪切应力 动脉粥样硬化 动脉瘤 血流动力学 |
| 收稿时间： | 2023-09-27 |
| 修稿时间： | 2023-11-03 |
The effect of wall shear stress on atherosclerosis and aneurysm |
| |
| LI Shuyan,TAO Xinyu,QU Chen. The effect of wall shear stress on atherosclerosis and aneurysm[J]. Chinese Journal of Arteriosclerosis, 2024, 32(5): 451-455 |
| |
| Authors: | LI Shuyan TAO Xinyu QU Chen |
| |
| Affiliation: | Department of Geriatrics, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210011, China |
| |
| Abstract: | Wall shear stress is an important parameter in hemodynamics. Normal wall shear stress maintains the physiological state of blood vessels, while abnormal wall shear stress is closely related to the pathological progression of atherosclerosis and aneurysm, which is one of the risk factors for the occurrence of malignant cardiovascular and cerebrovascular events. Abnormal wall shear stress destroys the normal function of endothelial cells through different pathogenesis, mediates the initiation and evolution of these two diseases. This article reviews the impact of wall shear stress on atherosclerosis and aneurysm based on literature research in recent years. |
| |
| Keywords: | wall shear stress； atherosclerosis； aneurysm； hemodynamics |
|
| 点击此处可从《中国动脉硬化杂志》浏览原始摘要信息 |
|
点击此处可从《中国动脉硬化杂志》下载免费的PDF全文 |
|
