基于VOSviewer和CiteSpace知识图谱对绞股蓝研究热点与趋势分析

目的 运用文献计量学软件CiteSpace和VOSviewer对绞股蓝Gynostemma pentaphyllum的研究热点及发展趋势进行可视化分析，为其研究新思路提供参考。方法 以绞股蓝为关键词，检索中国知网（CNKI）、万方、维普数据库和Web of Science数据库中所收录的相关研究文献，采用CiteSpace、VOSviewer、WPS软件分别对绞股蓝中、英文文献的整体产出、研究主体、合作网络及关键词等进行可视化分析。结果 筛选纳入文献3 305篇，其中中文文献2 799篇，英文文献506篇。绞股蓝的年发文量总体呈现增长趋势，共有31个国家（地区）参与绞股蓝的研究，其中以中国为主。中、英文文献发文量最多的作者分别是谭华炳和朴香兰；辽宁中医药大学和中国科学院分别是中、英文文献发文量最多的机构。研究领域内各机构和团队之间的交流合作有待加强。中、英文关键词共现、聚类分析显示，研究热点主要集中于绞股蓝的化学成分、提取工艺、药理作用、临床应用和作用机制方面。结论 绞股蓝研究目前仍处于上升阶段，未来绞股蓝多糖、氧化应激、分子对接、肠道微生物菌群及抗炎作用等方面是国内外绞股蓝领域应关注的研究重点。

Analysis of research hotspots and trends in Gynostemma pentaphyllum based on VOSviewer and CiteSpace knowledge graph

Objective The research hotspots and development trends of Jiaogulan (Gynostemma pentaphyllum) were analyzed visually through the bibliometric software CiteSpace and VOSviewer, so as to provide reference for finding new research ideas in China. Methods In this study, the publications with the keyword of G. pentaphyllum were retrieved and extracted from the CNKI,Wanfang and Wipro database and Web of Science database, respectively. Then, CiteSpace, VOSviewer, and WPS software were used to visualize and analyze the overall output, research subjects, collaborative networks, and keywords of the Chinese and English literatures. Results A total of 3 305 publications were consisted, including 2 799 in Chinese and 506 in English. The annual number of publications of G. pentaphyllum showed an increasing trend. China was the main country to study about G. pentaphyllum, while 31 countries (regions) in total. The authors with the most publications in Chinese and English literatures are Tan Huabing and Piao Xianglan. Liaoning University of Traditional Chinese Medicine and the Chinese Academy of Sciences are the institutions with the largest number of publications in Chinese and English respectively. In general, the institutions and research teams in the field is expected to strengthen the exchanges and cooperation. Keyword co-occurrence and cluster analysis in Chinese and English showed that the research hotspots mainly focused on the chemical composition, extraction process, pharmacological effect, clinical application and mechanism of action of G. pentaphyllum. Conclusion The research field of Gynostemma pentaphyllum is in the stage of development. In the future,more attention should be paid to the polysaccharides, oxidative stress, molecular docking, gut microflora and anti-inflammatory effects in the field of G. pentaphyllum at home and abroad.