中药调控氧化应激防治急性肺损伤的研究进展

急性肺损伤（acute lung injury，ALI）是临床常见的极危重症之一，其死亡率与发病率居高不下，早期以低氧血症、肺间质水肿及肺部炎症为主，后进一步发展成为急性呼吸窘迫综合症，表现为严重的缺氧性呼吸衰竭。氧化应激作为诱发ALI的作用机制之一，在其发生发展中扮演重要作用。中药可通过抑制炎症及氧化应激反应，减轻肺间质水肿，改善肺通气，恢复肺组织损伤等起到治疗ALI的作用。基于此，从氧化应激作用功能、调控ALI机制及中药干预机制等方面进行归纳总结，为ALI的临床研究及新药创新探索提供理论指导。

Research progress on the regulation of oxidative stress by traditional Chinese medicine in the prevention and treatment of acute lung injury

Acute lung injury (ALI) is one of the most common and critically ill diseases in clinical practice, with high mortality and morbidity. It is mainly characterized by hypoxemia, pulmonary interstitial edema and pulmonary inflammation in the early stage, and further develops into acute respiratory distress syndrome in the later stage, which is manifested as severe hypoxic respiratory failure. As one of the mechanisms inducing ALI, oxidative stress plays an important role in its occurrence and development. Traditional Chinese medicine can play a role in treating ALI by inhibiting inflammation and oxidative stress, alleviating pulmonary interstitial edema, improving lung ventilation, and restoring lung tissue damage. Based on this, this paper summarized the function of oxidative stress, the mechanism of regulating ALI and the intervention mechanism of traditional Chinese medicine, in order to provide theoretical guidance for clinical research and new drug innovation exploration of ALI.