A study on the action of vitamin E supplementation on plasminogen activator inhibitor type 1 and platelet nitric oxide production in type 2 diabetic patients |
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Authors: | Vignini Arianna Nanetti Laura Moroni Cinzia Testa Roberto Sirolla Cristina Marra Maurizio Manfrini Silvana Fumelli Daniele Marcheselli Fiorella Mazzanti Laura Rabini Rosa Anna |
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Affiliation: | aInstitute of Biochemistry, School of Medicine, Polytechnic University of Marche, Via P. Ranieri 65, 60131 Ancona, Italy;bINRCA, Italian National Research Center on Aging, Ancona, Italy;cINRCA Centre of Citology, Ancona, Italy;dDiabetology Center, Senigallia Hospital, Senigallia-Ancona, Italy |
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Abstract: | Background and aimType 2 diabetic (T2DM) patients show decreased fibrinolysis, mainly linked to high plasminogen activator inhibitor type 1 (PAI-1) production, together with a reduced bioavailability of nitric oxide and an impairment in Na+/K+-ATPase activity possibly involved in increased cardiovascular risk. Vitamin E is the major natural lipid-soluble antioxidant in human plasma. The present work was conducted in order to measure PAI-1, ICAM and VCAM-1 plasma levels, platelet nitric oxide production and membrane Na+/K+-ATPase activity in type 2 diabetic subjects treated with vitamin E (500 IU/day) for 10 weeks and then followed for other 20 weeks.Methods and resultsThirty-seven T2DM patients (24 males and 13 females) were studied. None of them were affected by any other disease or diabetic complications. Significant differences were detected for PAI-1 antigen (p < 0.001), PAI-1 activity (p < 0.001), nitric oxide (NO) production (p < 0.001), and Na+/K+-ATPase activity (p < 0.001) among the 4 phases of the study. A significant decrease both in ICAM and VCAM-1 plasma levels was also found at the 10th week compared with baseline (respectively p < 0.001 and p < 0.05).ConclusionOur data suggest that vitamin E counteracts endothelial activation in T2DM patients possibly representing a new tool for endothelial protection. |
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Keywords: | Type 2 diabetes mellitus Vitamin E Plasminogen activator inhibitor type 1 Nitric oxide Na+/K+-ATPase |
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