华佗再造丸抗血栓作用及对实验性微循环障碍的影响

目的 观察华佗再造丸对血瘀证动物模型体内血栓，体外血栓的作用及对实验性微循环障碍的影响。方法 实验体国栓采用Ｃｈａｎｄｅｌ法，体内血栓采用动物颈动脉电流刺激法，高分子右旋糖酐造成动物循环障碍。结果 华佗再造丸具有抑制体外全形成、延长体内血栓作用并能降低动物的血液粘度、抑制血小板聚集性，改善动物脑供血供和软脑膜微循环障碍的功能。结论 华佗再造丸具有活血化瘀、拮抗血栓形成的功效，是治疗脑血栓后遗症的

Huatuo reconstruction pill prevents thrombosis and microcirculation disorders in experimental animals

Objective To study the effects of Huatuo reconstruction pill(HTRP) on prevention of in vitro and in vivo thrombosis and in improving microcirculation disorders in experimental animals. Methods A chandeler loop system, electric current stimulus, and intravenous injection of high molecular weight dextran into rabbits were used to creat in vitro thrombosis, in vivo thrombosis and microcirculatory disturbance, respectively. Results HTRP inhibited in vitro thrombosis, delayed thrombosis formation in neck artery and effetively decreased blood viscosity, platelet adhesion rate and aggregation rate. HTRP also improved brain ischemia and hypoxia, and improved the microcirculation disturbances. Conclusion HTRP can prevent cerebral thrombosis and improve microcirculation disturbance induced by high molecular weight dextran.The results suggest that HTRP is an effective antianginal medicine.