| 脑深部电刺激对帕金森病异动症大鼠纹状体谷氨酸和γ-氨基丁酸含量影响的研究 |
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| 引用本文： | 浦政,陆丽霞,刘振国. 脑深部电刺激对帕金森病异动症大鼠纹状体谷氨酸和γ-氨基丁酸含量影响的研究[J]. 脑与神经疾病杂志, 2009, 17(4): 241-244 |
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| 作者姓名： | 浦政 陆丽霞 刘振国 |
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| 作者单位： | 上海交通大学医学院附属新华医院神经科,上海,200092;上海交通大学医学院附属新华医院神经科,上海,200092;上海交通大学医学院附属新华医院神经科,上海,200092 |
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| 基金项目： | 教育部留学回国人员科研启动基金,上海市教育委员会基金,上海市浦江人才计划,上海市科委上海-飞利浦研究与发展基金合作基金 |
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| 摘 要： | 目的观察脑深部电刺激对异动症大鼠纹状体区神经递质的影响,探讨脑深部电刺激的可能作用机制。方法成功制备帕金森病、异动症和丘脑底核高频电刺激大鼠模型,随机分为"刺激组"、"假刺激组"和"假手术组",经高频电刺激实验后,用高效液相色谱分析法测定模型大鼠纹状体区谷氨酸和γ-氨基丁酸的含量。结果纹状体区谷氨酸含量表现为"假刺激组"和"假手术组"毁损侧高于毁损对侧,"刺激组"毁损侧低于毁损对侧;在毁损侧"刺激组"含量低于"假刺激组"和"假手术组",在毁损对侧三组之间无差异。纹状体区γ-氨基丁酸含量表现为"假刺激组"和"假手术组"毁损侧高于毁损对侧,"刺激组"毁损侧低于毁损对侧;在毁损侧"刺激组"含量低于"假刺激组"和"假手术组",毁损对侧三组间无差异。结论STN-DBS治疗LID的机制可能与其在一定程度上改变基底节神经元兴奋状态以及矫正基底节直接与间接通路之间的失平衡相关。
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| 关 键 词： | 异动症 脑深部电刺激 丘脑底核 谷氨酸 γ-氨基丁酸 |
Glutamate and Gamma-aminobutyric acid in rat model corpus striatum of Levodopa-induced Dyskinesia with deep brain stimulation |
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| PU Zheng,LU Li-xia,LIU Zhen-guo. Glutamate and Gamma-aminobutyric acid in rat model corpus striatum of Levodopa-induced Dyskinesia with deep brain stimulation[J]. Journal of Brain and Nervous Diseases, 2009, 17(4): 241-244 |
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| Authors: | PU Zheng LU Li-xia LIU Zhen-guo |
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| Affiliation: | PU Zheng,LU Li-xia,LIU Zhen-guo. Xinhua Hospital Medical School of Shanghai Jiaotong University,Shanghai 200092,China |
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| Abstract: | Objective Study the neurotransmitters in corpus striatum of rat models of Levodopa-induced dyskinesia with deep brain stimulation and the probably mechanics of deep brain stimulation in treating Levodopa-induced dyskinesia.Methods The rat models of Parkinson's disease,Levodopa-induced dyskinesia and subthalamus nucleus deep brain stimulation were successfully set up.Three groups of stmulation,sham stimulation and sham plantation were divided at random.Each group was given corresponding stimulation test.The ... |
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| Keywords: | Levodopa-induced dyskinesia Deep brain stimulation Subthalamus nucleus Glutamate Gamma-aminobutyric acid |
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