新生儿窒息与自由基

45例新生儿按Apgar评分共分三组:轻度窒息,重度窒息及正常儿,均在生后24小时内测定血中超氧化物歧化酶(SOD)与脂质过氧化物(LPO)。结果表明:窒息儿血中SOD降低,LPO增高。窒息儿与正常儿之间均值差异有显著意义,而轻与重度窒息儿之间差异不大。因此Apgar评分仅代表出生时瞬间窒息状态,不能反映实际严重程度,也不能评估预后。窒息后SOD与LPO的变化证实自由基在窒息后再灌注损伤中起着重要作用,因而救治时应早期应用自由基清除剂。

Relationship Between Asphyxia of the Newborn and Free Radical

Forty-five newborns were divided into three groups according to the apgar scores: mild asphyxia, serious asphyxia and normal. A determination of superoxide dismutase (SOD) and peroxidation (LPO) within 24 h after birth showed that SOD decreased and LPO increased in newborns with asphyxia. These findings are concordant with those reported at home and abroad. There was a significant difference between the means of SOD and LPO in newborns with asphyxia and normal ones, whereas no significant difference in SOD and LPO levels was found between the mild asphyxia newborns and serious ones. It is thought that apgar score reflects the asphyxial status only for an instant after birth, doesn't reflect the degree of asphyxia and is not helpful in evaluating prognosis. The alteration of SOD and LPO after asphyxia of the newborn reveals that free radical plays an important role in injury due to reperfusion. Therefore, to treat asphyxia of newborns the cleaners for free redical should be used as carly as posible.