Safety and immunogenicity of recombinant poxvirus HIV-1 vaccines in young adults on highly active antiretroviral therapy |
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| Authors: | Greenough Thomas C Cunningham Coleen K Muresan Petronella McManus Margaret Persaud Deborah Fenton Terry Barker Piers Gaur Aditya Panicali Dennis Sullivan John L Luzuriaga Katherine;Pediatric AIDS Clinical Trials Group P Team |
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| Institution: | Pediatrics and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA. thomas.greenough@umassmed.edu |
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| Abstract: | A trial to evaluate the safety and immunogenicity of recombinant modified vaccinia Ankara (MVA) and fowlpox (FP) vectors expressing multiple HIV-1 proteins was conducted in twenty HIV-1 infected youth with suppressed viral replication on HAART. The MVA and FP-based multigene HIV-1 vaccines were safe and well tolerated. Increased frequencies of HIV-1 specific CD4+ proliferative responses and cytokine secreting cells were detected following immunization. Increased frequencies and breadth of HIV-1 specific CD8 T-cell responses were also detected. Plasma HIV-1-specific antibody levels and neutralizing activity were unchanged following vaccination. Poxvirus-based vaccines may merit further study in therapeutic vaccine protocols. |
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