术后放疗联合同步化疗治疗脑恶性胶质瘤疗效观察

目的回顾性分析脑恶性胶质瘤术后放化疗联合治疗临床疗效。方法对资料完整的126例脑恶性胶质瘤患者进行回顾性研究，分为单纯放疗组（64例）、给予术后单纯放疗和放化疗联合组（62例）、给予放疗后替尼泊苷联合司莫司汀化疗，对组间生存差异进行比较。结果成人恶性胶质瘤术后单纯放疗组1、3、5年生存率分别为64．06％、31．25％、15．63％；术后同步放化疗组1、3、5年生存率分别为80．65％、50％、30．65％。同步放化疗组生存率明显优于单纯放疗组（P〈0．05）。结论脑恶性胶质瘤术后放化疗联合治疗有较好疗效，毒副反应可以耐受，值得临床推广。

Postoperative Concurrent Radiotherapy and Chemotherapy for Malignant Cerebral Glioma

Objective To retrospectively analyze and evaluate the outcome of malignant cerebral glioma treated by chemotherapy plus radiotherapy.Methods A total of 126 patients with malignant cerebral glioma were retrospectively studied.Sixty-four patients in the radiotherapy group were irradiated with DT54-60 Gy,62 patients in the chemotherapy plus radiotherapy group were given chemotherapy(VM-26 and Me-CCNU)after exposure to DT 20 Gy.The 1-,3-and 5-year survival rates of these patients were compared.Results The 1-,3-,and 5-year survival rates of the radiotherapy group were 64.06%,31.25%,and 15.63% respectively,while the 1-,3-,and 5-year survival rates of the chemotherapy plus radiotherapy group were 80.65%,50%,and 30.65 % respectively(P <0.05).Conclusion Combination of chemotherapy and radiotherapy is effective and well-tolerated in the treatment of malignant cerebral glioma.