| 枣杞合剂拮抗环磷酰胺对小鼠毒副作用的效应观察 |
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| 引用本文： | 文志斌,汉建忠,何晓凡,刘发益,熊石龙,李俊成,贺石林. 枣杞合剂拮抗环磷酰胺对小鼠毒副作用的效应观察[J]. 湖南中医药大学学报, 2001, 21(4): 21-23 |
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| 作者姓名： | 文志斌 汉建忠 何晓凡 刘发益 熊石龙 李俊成 贺石林 |
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| 作者单位： | 中南大学湘雅医学院生理教研室, |
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| 基金项目： | 国家教育部优秀青年教师资助课题 (教人司 [2 0 0 1] 3 9号 ) |
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| 摘 要： | 目的：观察枣杞合剂对小鼠是否具有拮抗环磷酰胺毒副作用的不良效应，为临床提供有效的化疗辅助药物。方法：对小鼠行大剂量环磷酰胺（CY）腹腔注射，并用枣杞合剂灌胃预防，以观察枣杞合剂对CY毒副作用的影响。结果：注射CY后，CY组小鼠外周血中红细胞、白细胞、血小板和血红蛋白计数明显降低，碳粒清除率明显下降，至实验第18d全部死亡；而枣杞合剂能明显延长小鼠的存活时间，增加单核－吞噬细胞系统的碳粒廓清率，升高外周血中红细胞、白细胞、血小板和 血红蛋白计数，与CY组相比，P＜0．01。结论：枣杞合剂具有拮抗CY对小鼠毒副作用的效应。
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| 关 键 词： | 枣杞合剂 环磷酰胺 毒副作用 动物实验 补中益气 中药 |
| 文章编号： | 1000-5633(2001)04-0021-03 |
| 修稿时间： | 2001-06-25 |
Effects of Zaoqi Mixture on Resistance to Side-effects of Cyclophosphamide in Mice |
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| Wen Zhibin,Han Jianzhong,He Xiaofan,et al. Effects of Zaoqi Mixture on Resistance to Side-effects of Cyclophosphamide in Mice[J]. Journal of Traditional Chinese Medicine University of Hunan, 2001, 21(4): 21-23 |
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| Authors: | Wen Zhibin Han Jianzhong He Xiaofan et al |
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| Abstract: | Objective:To evaluate the preventive effects of Zaoqi mixture (ZQM) on resistance to side-effects of cyclophosphamide (CY) in mice. Methods: Mice were at random divided into the control, CY,CY plus leucogen and CY plus ZQM groups. After the injection of leucogen or ZQM ,CY was intraperitoneally injected in high dose and the preventive effects of ZQM on resistance to side-effects of CY were observed. Results: As compared with the single CY and the CY plus leucogen groups, ZQM significantly prolonged the survival time and increased the RBC, WBC and platelet counts in peripheral blood in the CY treated mice. In addition, ZQM also increased clearance of carbon particles from circulating blood of the CY treated mice.Conclusion:ZQM may have the function of antagonizing the side-effects of CY in mice. |
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| Keywords: | Zaoqi mixture cyclophosphamide side-effect animal mouse invigorating spleen to replenish Qi |
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