Non-specific immunity to Plasmodium falciparum: in vitro studies |
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Authors: | GA Butcher RL Clancy |
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Institution: | Pathology, D.M.C.S.B. Royal Newcastle Hospital, Newcastle, NSW 2300, Australia |
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Abstract: | Peripheral blood mononuclear cells (PBM) were cultured with Plasmodium falciparum malaria for several cycles of parasite growth. Non-immune PBM inhibited P. falciparum more frequently than immune PBM. The inhibiting factor appears to be released during the first 24 hours of culture and is a non-dialysable factor, probably originating from monocytes. The relevance of these findings to in vivo immunity is discussed. |
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