| 溴吡斯的明缓释片的药代动力学和相对生物利用度研究 |
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| 引用本文： | 谭群友,熊华蓉,王睿,李艺,张景勍. 溴吡斯的明缓释片的药代动力学和相对生物利用度研究[J]. 第三军医大学学报, 2011, 33(5): 511-514 |
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| 作者姓名： | 谭群友 熊华蓉 王睿 李艺 张景勍 |
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| 作者单位： | 谭群友,Tan Qunyou(第三军医大学大坪医院野战外科研究所胸外科,重庆,400042);熊华蓉,王睿,李艺,张景勍,Xiong Huarong,Wang Rui,Li Yi,Zhang Jingqing(重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室,重庆,400016) |
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| 基金项目： | 教育部博士培养基金，重庆市教育委员会"首批高等学校优秀人才"资助项目，第三军医大学临床科研基金 |
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| 摘 要： | 目的 研究溴吡斯的明缓释片与其普通片在兔体内的药代动力学与相对生物利用度.方法 6只新西兰兔随机分成2组,采用自身交叉对照实验,单剂量口服溴吡斯的明缓释片或普通片后,采用高效液相色谱法测定血浆中溴吡斯的明浓度,计算药动学参数和相对生物利用度.结果 溴吡斯的明普通片与缓释片给药后,药动学参数如下:tmax分别为2 h和 ...
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| 关 键 词： | 溴吡斯的明缓释片 药代动力学 相对生物利用度 |
Pharmacokinetics and relative bioavailability of pyridostigmine bromide sustained-release tablets in rabbits |
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| Tan Qunyou,Xiong Huarong,Wang Rui,Li Yi,Zhang Jingqing. Pharmacokinetics and relative bioavailability of pyridostigmine bromide sustained-release tablets in rabbits[J]. Acta Academiae Medicinae Militaris Tertiae, 2011, 33(5): 511-514 |
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| Authors: | Tan Qunyou Xiong Huarong Wang Rui Li Yi Zhang Jingqing |
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| Affiliation: | qing2(1 Center of Thoracic Surgery,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing,400042;2Medicine Engineering Research Center,Key Laboratory of Biochemical and Molecular Pharmacology,Chongqing Medical University,Chongqing,400016,China) |
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| Abstract: | Objective To study the pharmacokinetics and relative bioavailability of pyridostigmine bromide sustained-release tablets and conventional tablets in rabbits.Methods Six New Zealand rabbits were randomly and evenly divided into two groups.Based on the self-crossover control experiment,the rabbits were subjected to single-dose oral administration of pyridostigmine bromide sustained-release tablets and conventional tablets.The pyridostigmine bromide concentrations in the plasma of rabbits were measured by high-performance liquid chromatography,based on which the pharmacokinetic parameters and relative bioavailability were calculated.Results After delivery,pyridostigmine bromide sustained-release tablets and conventional tablets had the following pharmacokinetic parameters: tmax = 2 h and 4 h;Cmax = 17.944 0.991 mg/L and 15.442±0.215 mg/L;AUC0-∞ = 201.956±4.623 mg/(h·L) and 200.557±3.357 mg/(h·L).When compared with conventional tablets,sustained-release tablets had relative bioavailability of 102.89%.Conclusion Pyridostigmine bromide sustained-release tablets have an obvious sustained-release effect,and are bioequivalent to conventional tablets. |
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| Keywords: | pyridostigmine bromide sustained-release tablets pharmacokinetics relative bioavailability |
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